PDF(Pubmed)
Abstract：
UNASSIGNED: Increased arterial stiffness and low handgrip strength (HGS) are associated with poor health outcomes and are a severe health risk for older adults. However, there is limited evidence and mixed results on whether there is an association between them. Therefore, this study focused on the association between arterial stiffness and HGS in relatively healthy older adults in Beijing, China.
UNASSIGNED: In 2016, 2,217 adult volunteers were recruited in Beijing. Brachial-ankle pulse wave velocity (baPWV) and the ankle-brachial index were measured using an automatic vascular profiling system. Carotid artery intima-media thickness and common carotid artery-internal diameter (CCAID) were evaluated using Doppler ultrasound, and HGS was measured with a dynamometer. Low HGS was determined using the Asian Sarcopenia Working Group 2019 criteria. Multivariate linear and logistic regressions evaluated the relationship between arterial stiffness and HGS.
UNASSIGNED: Ultimately, 776 relatively healthy older adults (mean age 69.05 ± 6.46 years) were included. Based on the AWGS2019 criteria, 137 participants were defined as having low HGS. Compared to the normal HGS group, the low HGS group was older and had higher baPWV (p < 0.001) but lower CCAID, body mass index (BMI) and hemoglobin (Hb) (p < 0.05). The multiple linear regression analysis revealed that baPWV was negatively correlated with HGS (β = -0.173, t = -2.587, p = 0.01). Multivariate logistic regression analysis showed that baPWV and CCAID were associated with an increased risk of low HGS (odds ratio (OR) per SD increase: 1.318, p = 0.007; OR per SD increase: 0.541, p < 0.001).
UNASSIGNED: Arterial stiffness and HGS were significantly negatively correlated in relatively healthy Chinese older adults. Low HGS is associated with increased arterial stiffness. Encouraging exercise training to improve HGS, thereby reducing arterial stiffness and the risk of cardiovascular events, may be a simple and effective intervention.
UNASSIGNED: In 2016, 2,217 adult volunteers were recruited in Beijing. Brachial-ankle pulse wave velocity (baPWV) and the ankle-brachial index were measured using an automatic vascular profiling system. Carotid artery intima-media thickness and common carotid artery-internal diameter (CCAID) were evaluated using Doppler ultrasound, and HGS was measured with a dynamometer. Low HGS was determined using the Asian Sarcopenia Working Group 2019 criteria. Multivariate linear and logistic regressions evaluated the relationship between arterial stiffness and HGS.
UNASSIGNED: Ultimately, 776 relatively healthy older adults (mean age 69.05 ± 6.46 years) were included. Based on the AWGS2019 criteria, 137 participants were defined as having low HGS. Compared to the normal HGS group, the low HGS group was older and had higher baPWV (p < 0.001) but lower CCAID, body mass index (BMI) and hemoglobin (Hb) (p < 0.05). The multiple linear regression analysis revealed that baPWV was negatively correlated with HGS (β = -0.173, t = -2.587, p = 0.01). Multivariate logistic regression analysis showed that baPWV and CCAID were associated with an increased risk of low HGS (odds ratio (OR) per SD increase: 1.318, p = 0.007; OR per SD increase: 0.541, p < 0.001).
UNASSIGNED: Arterial stiffness and HGS were significantly negatively correlated in relatively healthy Chinese older adults. Low HGS is associated with increased arterial stiffness. Encouraging exercise training to improve HGS, thereby reducing arterial stiffness and the risk of cardiovascular events, may be a simple and effective intervention.
摘要：
■增加的动脉僵硬度和低握力（HGS）与不良的健康结果有关，并且对老年人来说是严重的健康风险。然而,关于两者之间是否存在关联的证据有限,结果参差不齐.因此,这项研究集中在北京相对健康的老年人的动脉僵硬度和HGS之间的关系，中国。
■2016年，北京招募了2217名成年志愿者。使用自动血管剖面系统测量臂踝脉搏波速度（baPWV）和踝肱指数。使用多普勒超声评估颈动脉内中膜厚度和颈总动脉内径（CCAID）。用测力计测量HGS。使用亚洲肌肉减少症工作组2019年标准确定低HGS。多元线性和逻辑回归评估了动脉僵硬度与HGS之间的关系。
■最终，包括776名相对健康的老年人（平均年龄69.05±6.46岁）。根据AWGS2019标准，137名参与者被定义为具有低HGS。与正常HGS组相比，低HGS组年龄较大，baPWV较高（p<0.001），但CCAID较低，体重指数(BMI)和血红蛋白(Hb)(p<0.05)。多元线性回归分析显示baPWV与HGS呈负相关(β=-0.173,t=-2.587,p=0.01)。多因素logistic回归分析显示，baPWV和CCAID与低HGS的风险增加相关（每SD增加的比值比（OR）：1.318，p=0.007；每SD增加的OR：0.541，p<0.001）。
■在相对健康的中国老年人中，动脉僵硬度和HGS呈显著负相关。低HGS与增加的动脉僵硬度相关。鼓励运动训练以改善HGS，从而降低动脉僵硬度和心血管事件的风险，可能是一种简单有效的干预措施。
■2016年，北京招募了2217名成年志愿者。使用自动血管剖面系统测量臂踝脉搏波速度（baPWV）和踝肱指数。使用多普勒超声评估颈动脉内中膜厚度和颈总动脉内径（CCAID）。用测力计测量HGS。使用亚洲肌肉减少症工作组2019年标准确定低HGS。多元线性和逻辑回归评估了动脉僵硬度与HGS之间的关系。
■最终，包括776名相对健康的老年人（平均年龄69.05±6.46岁）。根据AWGS2019标准，137名参与者被定义为具有低HGS。与正常HGS组相比，低HGS组年龄较大，baPWV较高（p<0.001），但CCAID较低，体重指数(BMI)和血红蛋白(Hb)(p<0.05)。多元线性回归分析显示baPWV与HGS呈负相关(β=-0.173,t=-2.587,p=0.01)。多因素logistic回归分析显示，baPWV和CCAID与低HGS的风险增加相关（每SD增加的比值比（OR）：1.318，p=0.007；每SD增加的OR：0.541，p<0.001）。
■在相对健康的中国老年人中，动脉僵硬度和HGS呈显著负相关。低HGS与增加的动脉僵硬度相关。鼓励运动训练以改善HGS，从而降低动脉僵硬度和心血管事件的风险，可能是一种简单有效的干预措施。
