PDF(Pubmed)
Abstract：
Burkholderia cepacia (B. cepacia) complex is a highly resistant gram-negative pathogen known to cause lung infection in cystic fibrosis, chronic granulomatous disease, and immunocompromised patients. However, it may rarely infect immunocompetent patients as well. Here, we present the case of a 30-year-old male patient who was treated for B. cepacia pneumonia in the hospital, discharged with oral antibiotics, and returned two months later with recurring B. cepacia pneumonia and bacteremia. The patient rapidly declined over the next 24 hours and expired in the intensive care unit. This case is significant as it is one of very few published cases of cepacia syndrome in a patient with no evidence of immunodeficiency. In conclusion, cases of B. cepacia pneumonia must be monitored vigilantly for progression to cepacia syndrome, even in immunocompetent patients. Additional studies regarding optimized antibiotic regimens and effective treatment modalities for B. cepacia infection are warranted.
摘要：
洋葱伯克霍尔德菌(B.洋葱）复合物是一种高度耐药的革兰氏阴性病原体，已知会导致囊性纤维化中的肺部感染，慢性肉芽肿病，和免疫功能低下的患者。然而,它也很少感染有免疫能力的患者。这里,我们介绍了一名30岁的男性患者，该患者在医院接受了洋葱芽孢杆菌肺炎的治疗，口服抗生素出院，并在两个月后因反复发作的洋葱芽孢杆菌肺炎和菌血症而返回。患者在接下来的24小时内迅速下降，并在重症监护病房过期。该病例具有重要意义，因为它是极少数没有免疫缺陷证据的患者中已发表的洋葱综合征病例之一。总之,必须警惕地监测洋葱芽孢杆菌肺炎的病例是否进展为洋葱综合征，即使在有免疫能力的患者中。关于优化的抗生素方案和有效的治疗方式的其他研究是必要的。
