PDF(Pubmed)
Abstract：
Hypokalemic periodic paralysis (hypoPP) is a rare channelopathy caused by mutations in skeletal muscle ion channels that usually occurs in young individuals and adolescents. The etiology can be attributed to various factors, such as idiopathic or secondary causes. It is characterized by episodes of sudden flaccid muscle weakness. Timely detection may mitigate the risk of severe complications. Secondary causes of hypoPP, such as hyperthyroidism, should be ruled out, as this could lead to thyrotoxic periodic paralysis. We report the case of a 19-year-old boy who presented to the ED with severe weakness in both the upper and lower extremities. The weakness rapidly progressed to his trunk and was accompanied by acute urinary retention. The physical examination was significant for bilateral upper and lower extremity weakness. Subsequent laboratory investigations revealed markedly low serum potassium levels. The patient\'s symptoms resolved after the replacement of potassium, and he was discharged without neurological deficits. Although rarely accompanied by acute urinary retention, hypoPP must be differentiated from other causes of weakness and paralysis so that the proper treatment can be initiated quickly. The rarity of hypoPP, a condition seldom encountered in clinical practice, and the added rarity of its coexistence with acute urinary retention further underscore the uniqueness of this case report.
摘要：
低钾性周期性麻痹（hypoPP）是一种罕见的由骨骼肌离子通道突变引起的通道病，通常发生在年轻人和青少年中。病因可以归因于各种因素，如特发性或继发性原因。它的特征是突然松弛的肌肉无力发作。及时检测可以减轻严重并发症的风险。低PP的次要原因，比如甲状腺功能亢进,应该排除,因为这可能导致甲状腺毒性周期性瘫痪。我们报告了一个19岁男孩的病例，该男孩在上肢和下肢均出现严重虚弱。无力迅速发展到他的躯干，并伴有急性尿潴留。体格检查对双侧上下肢无力具有重要意义。随后的实验室调查显示血清钾水平明显较低。患者的症状在更换钾后得到缓解,他没有神经缺陷就出院了.虽然很少伴有急性尿潴留，hypoPP必须与虚弱和瘫痪的其他原因区分开来，以便迅速开始适当的治疗。hypopp的稀有，在临床实践中很少遇到的情况，与急性尿潴留共存的罕见性进一步强调了该病例报告的独特性。
