PDF(Pubmed)
Abstract：
UNASSIGNED: To investigate the characteristics of brain structure in children with focal cortical dysplasia (FCD)-induced pharmacoresistant epilepsy, and explore the potential mechanisms of cognitive impairment from the view of gray matter alteration.
UNASSIGNED: 25 pharmacoresistant pediatric patients with pathologically confirmed focal cortical dysplasia (FCD), and 25 gender-matched healthy controls were included in this study. 3.0T MRI data and intelligence tests using the Wechsler Intelligence Scale for Children-Forth Edition (WISC-IV) were generated for all subjects. Voxel-based morphometry (VBM)-diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) and surface-based morphometry (SBM) analyses were performed to analyze gray matter volume and cortical structure. Two-sample t-tests were used to compare the differences in gray matter volume (P＜0.05, FWE) and cortical thickness (P＜0.001, FWE) between the two groups. Also, the Spearman rank correlation analyses were employed to determine the relationship between structural alterations and neuropsychological results.
UNASSIGNED: The WISC-IV scores of the FCD group were significantly lower than those of the HC group in terms of full-scale intelligence quotient (FSIQ), verbal comprehension index (VCI), perceptual reasoning index (PRI), working memory index (WMI), and processing speed index (PSI) (all P＜0.01). Compared with the HC group, in the FCD group, the gray matter volume (GMV) reduced significantly in the left cerebellum_8, cerebellum_Crus2, and bilateral thalamus (P＜0.05, FWE); the GMV increased in the bilateral medial frontal gyrus, right precuneus, and left inferior temporal gyrus (P＜0.05, FWE), and the cortical thickness increased in the bilateral frontal, parietal, and temporal areas (P＜0.001, FWE). Correlation analyses showed that the age of seizure onset had positive correlations with the WISC-IV scores significantly. Meanwhile, the cortex thicknesses of the left pars opercularis gyrus, left middle temporal gyrus, and right inferior temporal gyrus had negative correlations with the WISC-IV scores significantly.
UNASSIGNED: FCD patients showed subtle structural abnormalities in multiple brain regions, with significant involvement of the primary visual cortex and language function cortex. And we also demonstrated a crucial correlation between gray matter structural alteration and cognitive impairment.
UNASSIGNED: 25 pharmacoresistant pediatric patients with pathologically confirmed focal cortical dysplasia (FCD), and 25 gender-matched healthy controls were included in this study. 3.0T MRI data and intelligence tests using the Wechsler Intelligence Scale for Children-Forth Edition (WISC-IV) were generated for all subjects. Voxel-based morphometry (VBM)-diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) and surface-based morphometry (SBM) analyses were performed to analyze gray matter volume and cortical structure. Two-sample t-tests were used to compare the differences in gray matter volume (P＜0.05, FWE) and cortical thickness (P＜0.001, FWE) between the two groups. Also, the Spearman rank correlation analyses were employed to determine the relationship between structural alterations and neuropsychological results.
UNASSIGNED: The WISC-IV scores of the FCD group were significantly lower than those of the HC group in terms of full-scale intelligence quotient (FSIQ), verbal comprehension index (VCI), perceptual reasoning index (PRI), working memory index (WMI), and processing speed index (PSI) (all P＜0.01). Compared with the HC group, in the FCD group, the gray matter volume (GMV) reduced significantly in the left cerebellum_8, cerebellum_Crus2, and bilateral thalamus (P＜0.05, FWE); the GMV increased in the bilateral medial frontal gyrus, right precuneus, and left inferior temporal gyrus (P＜0.05, FWE), and the cortical thickness increased in the bilateral frontal, parietal, and temporal areas (P＜0.001, FWE). Correlation analyses showed that the age of seizure onset had positive correlations with the WISC-IV scores significantly. Meanwhile, the cortex thicknesses of the left pars opercularis gyrus, left middle temporal gyrus, and right inferior temporal gyrus had negative correlations with the WISC-IV scores significantly.
UNASSIGNED: FCD patients showed subtle structural abnormalities in multiple brain regions, with significant involvement of the primary visual cortex and language function cortex. And we also demonstrated a crucial correlation between gray matter structural alteration and cognitive impairment.
摘要：
■探讨局灶性皮质发育不良（FCD）诱导的药物抵抗癫痫患儿的脑结构特征，并从灰质改变的角度探讨认知功能障碍的潜在机制。
■25例经病理证实为局灶性皮质发育不良（FCD）的耐药儿科患者，25名性别匹配的健康对照纳入本研究.使用韦氏儿童智力量表（WISC-IV）为所有受试者生成3.0TMRI数据和智力测试。进行了基于体素的形态计量学（VBM）-通过指数代数（DARTEL）和基于表面的形态计量学（SBM）分析的差异解剖配准，以分析灰质体积和皮质结构。采用双样本t检验比较两组间灰质体积(P＜0.05,FWE)和皮质厚度(P＜0.001,FWE)的差异。此外，Spearman等级相关分析用于确定结构改变与神经心理学结果之间的关系.
■FCD组的WISC-IV评分在全面智商（FSIQ）方面明显低于HC组，言语理解指数（VCI），感知推理指数(PRI)，工作记忆索引(WMI)，处理速度指数(PSI)(均P＜0.01)。与HC组相比，在FCD组，左侧小脑_8、小脑_Crus2、双侧丘脑的灰质体积(GMV)明显减少(P＜0.05,FWE);双侧额内侧回的GMV增加,右前叶,左颞下回(P＜0.05,FWE),双侧额叶皮质厚度增加,顶叶,和颞区（P＜0.001，FWE）。相关分析表明，癫痫发作年龄与WISC-IV评分呈显著正相关。同时,叶柄左回的皮层厚度，左颞中回,右侧颞下回与WISC-IV评分呈负相关。
■FCD患者在多个脑区表现出细微的结构异常，主要受累于初级视觉皮层和语言功能皮层。我们还证明了灰质结构改变与认知障碍之间的关键相关性。
■25例经病理证实为局灶性皮质发育不良（FCD）的耐药儿科患者，25名性别匹配的健康对照纳入本研究.使用韦氏儿童智力量表（WISC-IV）为所有受试者生成3.0TMRI数据和智力测试。进行了基于体素的形态计量学（VBM）-通过指数代数（DARTEL）和基于表面的形态计量学（SBM）分析的差异解剖配准，以分析灰质体积和皮质结构。采用双样本t检验比较两组间灰质体积(P＜0.05,FWE)和皮质厚度(P＜0.001,FWE)的差异。此外，Spearman等级相关分析用于确定结构改变与神经心理学结果之间的关系.
■FCD组的WISC-IV评分在全面智商（FSIQ）方面明显低于HC组，言语理解指数（VCI），感知推理指数(PRI)，工作记忆索引(WMI)，处理速度指数(PSI)(均P＜0.01)。与HC组相比，在FCD组，左侧小脑_8、小脑_Crus2、双侧丘脑的灰质体积(GMV)明显减少(P＜0.05,FWE);双侧额内侧回的GMV增加,右前叶,左颞下回(P＜0.05,FWE),双侧额叶皮质厚度增加,顶叶,和颞区（P＜0.001，FWE）。相关分析表明，癫痫发作年龄与WISC-IV评分呈显著正相关。同时,叶柄左回的皮层厚度，左颞中回,右侧颞下回与WISC-IV评分呈负相关。
■FCD患者在多个脑区表现出细微的结构异常，主要受累于初级视觉皮层和语言功能皮层。我们还证明了灰质结构改变与认知障碍之间的关键相关性。
