Abstract：
This perspective delves into the investigation of synthetic and naturally occurring inhibitors, their patterns of inhibition, and the effectiveness of newly utilized natural compounds as inhibitors targeting the Ornithine decarboxylase enzyme. This enzyme is known to target the MYC oncogene, thereby establishing a connection between polyamine metabolism and oncogenesis in both normal and cancerous cells. ODC activation and heightened polyamine activity are associated with tumor development in numerous cancers and fluctuations in ODC protein levels exert a profound influence on cellular activity for inhibition or suppressing tumor cells. This perspective outlines efforts to develop novel drugs, evaluate natural compounds, and identify promising inhibitors to address gaps in cancer prevention, highlighting the potential of newly designed synthetic moieties and natural flavonoids as alternatives. It also discusses natural compounds with potential as enhanced inhibitors.
摘要：
这个观点探讨了合成和天然抑制剂，他们的抑制模式，以及最近使用的天然化合物作为靶向MYC癌基因的鸟氨酸脱羧酶抑制剂的功效，并将多胺代谢与正常细胞和癌细胞的肿瘤发生联系起来。ODC活化和提高的多胺活性与许多癌症中的肿瘤发展有关,并且ODC蛋白水平的波动对抑制或抑制肿瘤细胞的细胞活性产生深远的影响。这个观点概述了开发新药物的努力，评估天然化合物，并确定有希望的抑制剂来解决癌症预防方面的差距，强调新设计的合成部分和天然类黄酮作为替代品的潜力。它还讨论了具有增强抑制剂潜力的天然化合物。
