Abstract：
Fracture-related infections are a challenging complication in orthopedic trauma that often necessitates multiple surgeries. Early administration of systemic antibiotics and surgical intervention remains the gold standard of care, but despite these measures, treatment failures can be as high as 35%. For these reasons, the introduction of local antibiotics at the site of at-risk fractures has increased over the past decade. This review looks at the various measures being used clinically including local antibiotic powder, polymethylmethacrylate, biodegradable substances, antibiotic-coated implants, and novel methods such as hydrogels and nanoparticles that have the potential for use in the future.
摘要：
骨折相关感染是骨科创伤中具有挑战性的并发症，通常需要多次手术。早期使用全身性抗生素和手术干预仍然是护理的黄金标准，但是尽管采取了这些措施，治疗失败可能高达35%。由于这些原因,在过去十年中,在高危骨折部位引入局部抗生素的情况有所增加.这篇综述着眼于临床上使用的各种措施，包括局部抗生素粉末，聚甲基丙烯酸甲酯,可生物降解的物质，抗生素涂层植入物，和新的方法，如水凝胶和纳米颗粒，具有在未来使用的潜力。
