Abstract：
Polycystic ovary syndrome(PCOS) is a highly prevalent endocrine and reproductive disorder characterized by ovulatory dysfunction, hyperandrogenism(HA), and polycystic ovarian morphology(PCOM). It is often accompanied by insulin resistance(IR), obesity, and metabolic disorders and can lead to cardiovascular diseases, endometrial carcinoma and many other late complications, seriously affecting the physical and mental health and quality of life in premenopausal women. The etiology of PCOS is still unknown and many scholars assume that mitochondrial dysfunction may represent a major pathogenic factor in PCOS in recent years. With a holistic view, treatment based on syndrome differentiation, and multi-system and multi-target treatment manner, traditional Chinese medicine(TCM) can mitigate the symptoms and signs of PCOS from multiple aspects. Although there have been reviews on the mechanism of mitochondrial dysfunction in PCOS, there is still a lack of reviews on the intervention of mitochondrial function by TCM to treat PCOS. Therefore, this paper focuses on the role of mitochondrial dysfunction in PCOS and summarizes the studies about the TCM intervention of PCOS by regulating the mitochondrial function, inflammation, oxidative stress(OS), autophagy, and apoptosis in the last five years, aiming to shed new light on the prevention and treatment of PCOS with TCM.
摘要：
多囊卵巢综合征（PCOS）是一种以排卵功能障碍为特征的内分泌和生殖疾病，高雄激素血症（HA），多囊卵巢形态学（PCOM）。它通常伴有胰岛素抵抗（IR），肥胖，和代谢紊乱，并可能导致心血管疾病，子宫内膜癌和许多其他晚期并发症，严重影响绝经前妇女的身心健康和生活质量。PCOS的病因尚不清楚，近年来许多学者认为线粒体功能障碍可能是PCOS的主要致病因素。从整体的角度来看，辨证论治,多系统多靶点治疗方式，中医药可从多个方面缓解PCOS的症状和体征。尽管对PCOS线粒体功能障碍的机制进行了综述，目前尚缺乏中医药干预线粒体功能治疗PCOS的综述。因此,本文就线粒体功能障碍在PCOS中的作用进行综述,炎症,氧化应激（OS），自噬,在过去的五年里，旨在为中医药防治PCOS提供新的思路。
