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Abstract：
OBJECTIVE: Numerous studies have investigated the relationships between nutritional status and the prognosis of ovarian cancer (OC). However, the majority of these studies have focused on pre-chemotherapy malnutrition, with limited attention given to dynamic changes in nutritional status during chemotherapy and the associated risk factors affecting the prognostic nutritional index (PNI) in OC women. This study aims to explore the variation trend in the nutritional status of OC women over time during chemotherapy and assess its predictive factors.
METHODS: A prospective longitudinal study was conducted from January 2021 to August 2023. Body mass index (BMI), PNI, Nutritional Risk Screening (NRS) 2002, serum albumin, and prealbumin measurements were utilized to assess the nutritional status of OC women. Data were collected through face-to-face interviews before initial chemotherapy (T0) and during the first (T1), third (T2), and fifth (T3) cycles of chemotherapy. Generalized Estimating Equations (GEE) were employed for the analysis of potential predictive factors.
RESULTS: A total of 525 OC women undergoing chemotherapy completed the study. Significantly varied levels of BMI, PNI, and serum concentrations of hemoglobin, albumin, prealbumin, potassium, sodium, magnesium, and calcium were observed in these patients (p < 0.05). The prevalence of nutritional risk decreased over time during chemotherapy (p < 0.05). Nutritional parameters, including BMI, PNI, and the serum concentrations of albumin and prealbumin, exhibited an upward trend in nutritional status throughout the chemotherapy cycles (p < 0.05). Multivariate analysis indicated that higher levels of BMI, serum albumin, prealbumin, absolute lymphocyte count, and hemoglobin ≥ 110 g/L at admission were associated with elevated PNI after chemotherapy (β = 0.077, p = 0.028; β = 0.315, p < 0.001; β = 0.009, p < 0.001; β = 1.359, p < 0.001; β = - 0.637, p = 0.005).
CONCLUSIONS: Patients consistently demonstrated improvements in nutritional risk and status from the initiation to the completion of chemotherapy cycles. Nutritional monitoring of OC women, particularly those exhibiting abnormalities at the commencement of chemotherapy, is crucial. Targeted nutritional support programs should be developed to enhance the prognosis of OC women.
METHODS: A prospective longitudinal study was conducted from January 2021 to August 2023. Body mass index (BMI), PNI, Nutritional Risk Screening (NRS) 2002, serum albumin, and prealbumin measurements were utilized to assess the nutritional status of OC women. Data were collected through face-to-face interviews before initial chemotherapy (T0) and during the first (T1), third (T2), and fifth (T3) cycles of chemotherapy. Generalized Estimating Equations (GEE) were employed for the analysis of potential predictive factors.
RESULTS: A total of 525 OC women undergoing chemotherapy completed the study. Significantly varied levels of BMI, PNI, and serum concentrations of hemoglobin, albumin, prealbumin, potassium, sodium, magnesium, and calcium were observed in these patients (p < 0.05). The prevalence of nutritional risk decreased over time during chemotherapy (p < 0.05). Nutritional parameters, including BMI, PNI, and the serum concentrations of albumin and prealbumin, exhibited an upward trend in nutritional status throughout the chemotherapy cycles (p < 0.05). Multivariate analysis indicated that higher levels of BMI, serum albumin, prealbumin, absolute lymphocyte count, and hemoglobin ≥ 110 g/L at admission were associated with elevated PNI after chemotherapy (β = 0.077, p = 0.028; β = 0.315, p < 0.001; β = 0.009, p < 0.001; β = 1.359, p < 0.001; β = - 0.637, p = 0.005).
CONCLUSIONS: Patients consistently demonstrated improvements in nutritional risk and status from the initiation to the completion of chemotherapy cycles. Nutritional monitoring of OC women, particularly those exhibiting abnormalities at the commencement of chemotherapy, is crucial. Targeted nutritional support programs should be developed to enhance the prognosis of OC women.
摘要：
目的：大量研究探讨了营养状况与卵巢癌预后的关系。然而,这些研究大多集中在化疗前营养不良，对化疗期间营养状况的动态变化以及影响OC女性预后营养指数（PNI）的相关危险因素的关注有限。本研究旨在探讨OC女性化疗期间营养状况随时间的变化趋势，并评估其预测因素。
方法：一项前瞻性纵向研究于2021年1月至2023年8月进行。身体质量指数(BMI),PNI,营养风险筛查(NRS)2002，血清白蛋白，和前白蛋白测量用于评估OC妇女的营养状况。数据通过首次化疗前（T0）和首次化疗期间（T1）的面对面访谈收集，第三（T2），和第五（T3）化疗周期。采用广义估计方程(GEE)分析潜在的预测因素。
结果：共有525名接受化疗的OC妇女完成了这项研究。BMI水平明显不同，PNI,和血红蛋白的血清浓度，白蛋白,前白蛋白,钾，钠,镁，在这些患者中观察到钙（p<0.05）。化疗期间营养风险的发生率随着时间的推移而下降(p<0.05)。营养参数，包括BMI,PNI,血清白蛋白和前白蛋白的浓度,在整个化疗周期中，营养状况呈上升趋势(p<0.05)。多变量分析表明，较高的BMI水平，血清白蛋白,前白蛋白,绝对淋巴细胞计数，入院时血红蛋白≥110g/L与化疗后PNI升高相关(β=0.077,p=0.028;β=0.315,p<0.001;β=0.009,p<0.001;β=1.359,p<0.001;β=-0.637,p=0.005)。
结论：从化疗周期开始到结束，患者的营养风险和状态持续改善。OC妇女的营养监测，特别是那些在化疗开始时表现出异常的人，至关重要。应制定有针对性的营养支持计划，以改善OC妇女的预后。
方法：一项前瞻性纵向研究于2021年1月至2023年8月进行。身体质量指数(BMI),PNI,营养风险筛查(NRS)2002，血清白蛋白，和前白蛋白测量用于评估OC妇女的营养状况。数据通过首次化疗前（T0）和首次化疗期间（T1）的面对面访谈收集，第三（T2），和第五（T3）化疗周期。采用广义估计方程(GEE)分析潜在的预测因素。
结果：共有525名接受化疗的OC妇女完成了这项研究。BMI水平明显不同，PNI,和血红蛋白的血清浓度，白蛋白,前白蛋白,钾，钠,镁，在这些患者中观察到钙（p<0.05）。化疗期间营养风险的发生率随着时间的推移而下降(p<0.05)。营养参数，包括BMI,PNI,血清白蛋白和前白蛋白的浓度,在整个化疗周期中，营养状况呈上升趋势(p<0.05)。多变量分析表明，较高的BMI水平，血清白蛋白,前白蛋白,绝对淋巴细胞计数，入院时血红蛋白≥110g/L与化疗后PNI升高相关(β=0.077,p=0.028;β=0.315,p<0.001;β=0.009,p<0.001;β=1.359,p<0.001;β=-0.637,p=0.005)。
结论：从化疗周期开始到结束，患者的营养风险和状态持续改善。OC妇女的营养监测，特别是那些在化疗开始时表现出异常的人，至关重要。应制定有针对性的营养支持计划，以改善OC妇女的预后。
