PDF(Pubmed)
Abstract：
Orthobunyaviruses (order Bunyavirales, family Peribunyaviridae) in the Simbu serogroup have been responsible for widespread epidemics of congenital disease in ruminants. Australia has a national program to monitor arboviruses of veterinary importance. While monitoring for Akabane virus, a novel orthobunyavirus was detected. To inform the priority that should be given to this detection, a scoping review was undertaken to (1) characterise the associated disease presentations and establish which of the Simbu group viruses are of veterinary importance; (2) examine the diagnostic assays that have undergone development and validation for this group of viruses; and (3) describe the methods used to monitor the distribution of these viruses. Two search strategies identified 224 peer-reviewed publications for 33 viruses in the serogroup. Viruses in this group may cause severe animal health impacts, but only those phylogenetically arranged in clade B are associated with animal disease. Six viruses (Akabane, Schmallenberg, Aino, Shuni, Peaton, and Shamonda) were associated with congenital malformations, neurological signs, and reproductive disease. Diagnostic test interpretation is complicated by cross-reactivity, the timing of foetal immunocompetence, and sample type. Serological testing in surveys remains a mainstay of the methods used to monitor the distribution of SGVs. Given significant differences in survey designs, only broad mean seroprevalence estimates could be provided. Further research is required to determine the disease risk posed by novel orthobunyaviruses and how they could challenge current diagnostic and surveillance capabilities.
摘要：
正统病毒(布尼亚病毒,Simbu血清群中的Perbunyaviridae）是反刍动物先天性疾病广泛流行的原因。澳大利亚有一个国家计划来监测具有兽医重要性的虫媒病毒。在监测Akabane病毒时，检测到一种新的正畸病毒。要通知应优先考虑此检测，进行了范围审查,以(1)表征相关疾病的表现,并确定哪些辛布组病毒具有兽医学重要性;(2)检查已经开发和验证该组病毒的诊断试验;(3)描述用于监测这些病毒分布的方法.两种搜索策略确定了224份同行评审的出版物，涉及血清群中的33种病毒。该组中的病毒可能会对动物健康造成严重影响，但是只有那些在进化枝B中的系统发育排列与动物疾病相关。六种病毒（Akabane，施马伦贝格,艾诺,Shuni,Peaton,和Shamonda）与先天性畸形有关，神经体征,和生殖疾病。诊断测试解释因交叉反应而变得复杂，胎儿免疫能力的时机，和样品类型。调查中的血清学测试仍然是用于监测SGV分布的主要方法。鉴于调查设计的显著差异，只能提供广泛的平均血清阳性率估计。需要进一步的研究来确定由新型正双头病毒引起的疾病风险，以及它们如何挑战当前的诊断和监测能力。
