PDF(Pubmed)
Abstract：
Infections caused by acute respiratory viruses induce a systemic innate immune response, which can be measured by the increased levels of expression of inflammatory genes in immune cells. There is growing evidence that these acute viral infections, alongside transient transcriptomic responses, induce epigenetic remodeling as part of the immune response, such as DNA methylation and histone modifications, which might persist after the infection is cleared. In this article, we first review the primary mechanisms of epigenetic remodeling in the context of innate immunity and inflammation, which are crucial for the regulation of the immune response to viral infections. Next, we delve into the existing knowledge concerning the impact of respiratory virus infections on the epigenome, focusing on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Influenza A Virus (IAV), and Respiratory Syncytial Virus (RSV). Finally, we offer perspectives on the potential consequences of virus-induced epigenetic remodeling and open questions in the field that are currently under investigation.
摘要：
由急性呼吸道病毒引起的感染诱导全身性先天性免疫反应，这可以通过免疫细胞中炎症基因表达水平的增加来衡量。越来越多的证据表明这些急性病毒感染,除了瞬时转录组反应，诱导表观遗传重塑作为免疫反应的一部分，如DNA甲基化和组蛋白修饰，清除感染后可能会持续存在。在这篇文章中,我们首先回顾了先天免疫和炎症背景下表观遗传重塑的主要机制，这对于调节病毒感染的免疫反应至关重要。接下来,我们深入研究有关呼吸道病毒感染对表观基因组影响的现有知识，重点关注严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2），甲型流感病毒(IAV),和呼吸道合胞病毒（RSV）。最后,我们提供了关于病毒诱导的表观遗传重塑的潜在后果的观点，以及目前正在研究的领域中的悬而未决的问题。
