PDF(Pubmed)
Abstract：
Coronavirus disease 2019 (COVID-19) caused a severe epidemic due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have found that patients do not completely recover from acute infections, but instead, suffer from a variety of post-acute sequelae of SARS-CoV-2 infection, known as long COVID. The effects of long COVID can be far-reaching, with a duration of up to six months and a range of symptoms such as cognitive dysfunction, immune dysregulation, microbiota dysbiosis, myalgic encephalomyelitis/chronic fatigue syndrome, myocarditis, pulmonary fibrosis, cough, diabetes, pain, reproductive dysfunction, and thrombus formation. However, recent studies have shown that naringenin and naringin have palliative effects on various COVID-19 sequelae. Flavonoids such as naringin and naringenin, commonly found in fruits and vegetables, have various positive effects, including reducing inflammation, preventing viral infections, and providing antioxidants. This article discusses the molecular mechanisms and clinical effects of naringin and naringenin on treating the above diseases. It proposes them as potential drugs for the treatment of long COVID, and it can be inferred that naringin and naringenin exhibit potential as extended long COVID medications, in the future likely serving as nutraceuticals or clinical supplements for the comprehensive alleviation of the various manifestations of COVID-19 complications.
摘要：
2019年冠状病毒病（COVID-19）因严重急性呼吸道综合症冠状病毒-2（SARS-CoV-2）引起严重流行。最近的研究发现，患者不能从急性感染中完全恢复，但相反，患有各种SARS-CoV-2感染的急性后后遗症，被称为长COVID。长期COVID的影响可能是深远的，持续时间长达六个月，并出现一系列症状，如认知功能障碍，免疫失调，微生物群菌群失调，肌痛性脑脊髓炎/慢性疲劳综合征，心肌炎,肺纤维化，咳嗽,糖尿病,疼痛,生殖功能障碍，和血栓形成。然而,最近的研究表明，柚皮素和柚皮苷对各种COVID-19后遗症有缓解作用。黄酮类化合物如柚皮苷和柚皮苷，常见于水果和蔬菜，有各种积极的影响，包括减少炎症,预防病毒感染，并提供抗氧化剂。本文就柚皮苷和柚皮素治疗上述疾病的分子机制和临床效果进行探讨。它建议将它们作为治疗长期COVID的潜在药物，可以推断，柚皮苷和柚皮苷表现出作为延长长期COVID药物的潜力，在未来可能作为保健品或临床补充剂，以全面缓解COVID-19并发症的各种表现。
