PDF(Pubmed)
Abstract：
Background: Regenerative medicine is evolving with discoveries like the stromal vascular fraction (SVF), a diverse cell group from adipose tissue with therapeutic promise. Originating from fat cell metabolism studies in the 1960s, SVF\'s versatility was recognized after demonstrating multipotency. Comprising of cells like pericytes, smooth muscle cells, and, notably, adipose-derived stem cells (ADSCs), SVF offers tissue regeneration and repair through the differentiation and secretion of growth factors. Its therapeutic efficacy is due to these cells\' synergistic action, prompting extensive research. Methods: This review analyzed the relevant literature on SVF, covering its composition, action mechanisms, clinical applications, and future directions. An extensive literature search from January 2018 to June 2023 was conducted across databases like PubMed, Embase, etc., using specific keywords. Results: The systematic literature search yielded a total of 473 articles. Sixteen articles met the inclusion criteria and were included in the review. This rigorous methodology provides a framework for a thorough and systematic analysis of the existing literature on SVF, offering robust insights into the potential of this important cell population in regenerative medicine. Conclusions: Our review reveals the potential of SVF, a heterogeneous cell mixture, as a powerful tool in regenerative medicine. SVF has demonstrated therapeutic efficacy and safety across disciplines, improving pain, tissue regeneration, graft survival, and wound healing while exhibiting immunomodulatory and anti-inflammatory properties.
摘要：
背景：再生医学随着诸如基质血管分数（SVF）的发现而发展，来自脂肪组织的具有治疗前景的多样化细胞群。起源于1960年代的脂肪细胞代谢研究，SVF的多功能性在证明多能性后得到认可。由像周细胞这样的细胞组成，平滑肌细胞，and,特别是,脂肪干细胞（ADSCs），SVF通过分化和分泌生长因子提供组织再生和修复。它的治疗功效是由于这些细胞的协同作用，促使广泛的研究。方法:对SVF的相关文献进行分析,涵盖其组成，行动机制,临床应用，和未来的方向。从2018年1月到2023年6月，在PubMed等数据库中进行了广泛的文献检索，Embase,等。,使用特定的关键字。结果:系统的文献检索共获得473篇文献。16篇文章符合纳入标准，被纳入审查。这种严格的方法为对SVF的现有文献进行彻底和系统的分析提供了一个框架，提供了对这种重要细胞群体在再生医学中的潜力的有力见解。结论：我们的综述揭示了SVF的潜力，一种异质的细胞混合物，作为再生医学的强大工具。SVF已经证明了跨学科的治疗功效和安全性，改善疼痛，组织再生，移植物存活，和伤口愈合，同时表现出免疫调节和抗炎特性。
