PDF(Pubmed)
Abstract：
Companion animal ownership has evolved to new exotic animals, including small mammals, posing a new public health challenge, especially due to the ability of some of these new species to harbour zoonotic bacteria, such as Salmonella, and spread their antimicrobial resistances (AMR) to other bacteria through the environment they share. Therefore, the objective of the present pilot study was to evaluate the current epidemiological AMR situation in commensal Escherichia coli and Salmonella spp., in non-traditional companion animal small mammals in the Valencia region. For this purpose, 72 rectal swabs of nine different species of small mammals were taken to assess the antimicrobial susceptibility against 28 antibiotics. A total of one Salmonella enterica serovar Telelkebir 13,23:d:e,n,z15 and twenty commensal E. coli strains were isolated. For E. coli strains, a high prevalence of AMR (85%) and MDR (82.6%) was observed, although neither of them had access outside the household. The highest AMR were observed in quinolones, one of the highest priority critically important antimicrobials (HPCIAs) in human medicine. However, no AMR were found for Salmonella. In conclusion, the results showed that small mammals\' commensal E. coli poses a public health risk due to the high AMR found, and the ability of this bacterium to transmit its resistance genes to other bacteria. For this reason, this pilot study highlighted the need to establish programmes to control AMR trends in the growing population of new companion animals, as they could disseminate AMR to humans and animals through their shared environment.
摘要：
伴侣动物所有权已经演变成新的外来动物，包括小型哺乳动物，构成新的公共卫生挑战，特别是由于这些新物种中的一些能够携带人畜共患细菌，比如沙门氏菌,并通过它们共享的环境将它们的抗微生物耐药性（AMR）传播给其他细菌。因此,本试验研究的目的是评估共生大肠杆菌和沙门氏菌的AMR流行病学现状。,在瓦伦西亚地区的非传统伴侣动物小哺乳动物中。为此,对9种不同种类的小型哺乳动物的72个直肠拭子进行了评估，以评估其对28种抗生素的抗菌素敏感性。共有1株肠道沙门氏菌Telelkebir13,23:d:e,n,分离出Z15和20个共生大肠杆菌菌株。对于大肠杆菌菌株，观察到AMR（85％）和MDR（82.6％）的高患病率，尽管他们俩都无法进入家庭之外。在喹诺酮类药物中观察到最高的AMR，人类医学中最重要的重要抗菌药物（HPCIA）之一。然而,没有发现沙门氏菌的AMR。总之,结果表明，由于发现的高AMR，小型哺乳动物的共生大肠杆菌构成了公共健康风险，以及这种细菌将其抗性基因传递给其他细菌的能力。出于这个原因,这项试点研究强调了需要制定计划，以控制不断增长的新伴侣动物种群的AMR趋势，因为他们可以通过共同的环境将AMR传播给人类和动物。
