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Abstract：
One of the characteristic features of ovarian cancer is its early dissemination. Metastasis and the invasiveness of ovarian cancer are strongly dependent on the phenotypical and molecular determinants of cancer cells. Invasive cancer cells, circulating tumor cells, and cancer stem cells, which are responsible for the metastatic process, may all undergo different modes of transition, giving rise to mesenchymal, amoeboid, and redifferentiated epithelial cells. Such variability is the result of the changing needs of cancer cells, which strive to survive and colonize new organs. This would not be possible if not for the variety of migration modes adopted by the transformed cells. The most common type of metastasis in ovarian cancer is dissemination through the transcoelomic route, but transitions in ovarian cancer cells contribute greatly to hematogenous and lymphatic dissemination. This review aims to outline the transition modes of ovarian cancer cells and discuss the migratory capabilities of those cells in light of the known ovarian cancer metastasis routes.
摘要：
卵巢癌的特征之一是其早期传播。卵巢癌的转移和侵袭强烈依赖于癌细胞的表型和分子决定因素。侵袭性癌细胞,循环肿瘤细胞，和癌症干细胞，负责转移过程，都可能经历不同的过渡模式，产生间充质，变形虫,再分化的上皮细胞.这种变异性是癌细胞需求变化的结果，他们努力生存和殖民新器官。如果不是转化细胞采用的各种迁移模式,这将是不可能的。卵巢癌中最常见的转移类型是通过腔内途径传播，但是卵巢癌细胞的转变极大地促进了血源性和淋巴传播。本文旨在概述卵巢癌细胞的过渡模式，并根据已知的卵巢癌转移途径讨论这些细胞的迁移能力。
