PDF(Pubmed)
Abstract：
Natural compounds, known for diverse pharmacological properties, have attracted attention as potential sources for hypertension treatment. Previous studies have revealed the hypotensive effect and vascular relaxation of prunetin, a natural compound derived from Prunus yedoensis. However, the potential blood pressure-lowering and vasorelaxant effects of sakuranetin, another representative compound found in plants belonging to the genus Prunus, have remained unexplored. We aimed to fill this gap by investigating the hypotensive and vasorelaxant effects of sakuranetin in rats. Results indicated that sakuranetin, particularly in the sakuranetin 20 mg/kg group, led to significant reductions in systolic blood pressure (SBP) and diastolic blood pressure (DBP) by -14.53 ± 5.64% and -19.83 ± 6.56% at 4 h after administration. In the sakuranetin 50 mg/kg group, the SBP and DBP decreased by -13.27 ± 6.86% and -16.62 ± 10.01% at 2 h and by -21.61 ± 4.49% and -30.45 ± 5.21% at 4 h after administration. In addition, we identified the vasorelaxant effects of sakuranetin, attributing its mechanisms to the inhibition of calcium influx and the modulation of angiotensin II. Considering its hypotensive and vasorelaxant effects, sakuranetin could potentially serve as an antihypertensive agent. However, further research is required to evaluate the safety and long-term efficacy.
摘要：
天然化合物,以不同的药理特性而闻名，作为高血压治疗的潜在来源引起了人们的关注。以前的研究已经揭示了prunetin的降压作用和血管舒张作用，一种来自麦子的天然化合物。然而,Sakuranetin潜在的降血压和血管舒张作用，在李属植物中发现的另一种代表性化合物，仍未探索。我们旨在通过研究sakuranetin对大鼠的降压和血管舒张作用来填补这一空白。结果表明，sakuranetin，特别是在Sakuranetin20mg/kg组中，给药后4小时，收缩压（SBP）和舒张压（DBP）显着降低-14.53±5.64％和-19.83±6.56％。在Sakuranetin50mg/kg组中，给药后2h，SBP和DBP分别降低-13.27±6.86％和-16.62±10.01％，4h分别降低-21.61±4.49％和-30.45±5.21％。此外,我们确定了sakuranetin的血管松弛作用，将其机制归因于钙内流的抑制和血管紧张素II的调节。考虑到它的降压和血管舒张作用,sakuranetin可能作为抗高血压药。然而,需要进一步的研究来评估安全性和长期疗效.
