PDF(Pubmed)
Abstract：
Evidence for acute or long-term coronavirus disease 2019 (COVID-19) infection is relatively limited. We aimed to evaluate the impact of COVID-19 infection on health-related quality of life (HRQoL) in the Japanese population. Eligible study participants were 13,365 employees and their dependents who answered questionnaires at baseline and 18 months later and who had at least 6 months of continuous enrolment before and after baseline. Of the 711 study participants who developed COVID-19 infection, 29.0% reported a decline in HRQoL, whereas 25.2% of uninfected participants reported a decline. The adjusted odds ratios (95% confidence intervals) for the association between COVID-19 infection and declines in HRQoL in the age categories of less than 30 years, 30s, 40s, 50s, and 60 years or higher were 0.54 (0.15-1.92), 1.70 (1.03-2.81), 1.14 (0.82-1.57), 1.05 (0.77-1.42), and 0.87 (0.46-1.64), respectively. This study demonstrates a differential association between COVID-19 infection and declines in HRQoL by age group. A 1.7-fold increase in the odds of negative changes in HRQoL was observed in only those in their 30s. Further studies are needed to elucidate differences in the impact of COVID-19 infection on HRQoL between younger people such as those in their 30s and the older population.
摘要：
2019年急性或长期冠状病毒病（COVID-19）感染的证据相对有限。我们旨在评估COVID-19感染对日本人群健康相关生活质量（HRQoL）的影响。符合条件的研究参与者是13,365名员工及其家属，他们在基线和18个月后回答了问卷，并且在基线之前和之后至少有6个月的连续注册。在711名感染COVID-19的研究参与者中，29.0%报告HRQoL下降，而25.2%的未感染参与者报告下降.在30岁以下的年龄类别中，COVID-19感染与HRQoL下降之间的关联的调整后优势比(95%置信区间)，30s,40s,50s,60岁或以上为0.54(0.15-1.92)，1.70(1.03-2.81),1.14(0.82-1.57),1.05(0.77-1.42),和0.87（0.46-1.64），分别。这项研究表明，按年龄组划分，COVID-19感染与HRQoL下降之间存在不同的关联。仅在30多岁的人群中观察到HRQoL负面变化的几率增加了1.7倍。需要进一步的研究来阐明COVID-19感染对年轻人（如30多岁）和老年人之间HRQoL影响的差异。
