PDF(Pubmed)
Abstract：
Zinc finger and BTB domain-containing 20 (ZBTB20), which was initially identified in human dendritic cells, belongs to a family of transcription factors (TFs) with an N-terminal BTB domain and one or more C-terminal DNA-binding zinc finger domains. Under physiological conditions, ZBTB20 acts as a transcriptional repressor in cellular development and differentiation, metabolism, and innate immunity. Interestingly, multiple lines of evidence from mice and human systems have revealed the importance of ZBTB20 in the pathogenesis and development of cancers. ZBTB20 is not only a hotspot of genetic variation or fusion in many types of human cancers, but also a key TF or intermediator involving in the dysregulation of cancer cells. Given the diverse functions of ZBTB20 in both health and disease, we herein summarize the structure and physiological roles of ZBTB20, with an emphasis on the latest findings on tumorigenesis and cancer progression.
摘要：
锌指和含BTB结构域的20（ZBTB20），最初在人类树突状细胞中发现，属于具有N末端BTB结构域和一个或多个C末端DNA结合锌指结构域的转录因子(TF)家族。在生理条件下,ZBTB20在细胞发育和分化中充当转录抑制因子，新陈代谢，和先天免疫。有趣的是,来自小鼠和人类系统的多条证据揭示了ZBTB20在癌症的发病机制和发展中的重要性。ZBTB20不仅是许多人类癌症中遗传变异或融合的热点，也是参与癌细胞失调的关键TF或中介因子。鉴于ZBTB20在健康和疾病方面的不同功能，我们在此总结了ZBTB20的结构和生理作用，重点介绍了关于肿瘤发生和癌症进展的最新发现。
