PDF(Pubmed)
Abstract：
Biliverdin reductase-A (BVRA) is a multi-functional enzyme with a multitude of important roles in physiologic redox homeostasis. Classically, BVRA is well known for converting the heme metabolite biliverdin to bilirubin, which is a potent antioxidant in both the periphery and the brain. However, BVRA additionally participates in many neuroprotective signaling cascades in the brain that preserve cognition. Here, we review the neuroprotective roles of BVRA and bilirubin in the brain, which together constitute a BVRA/bilirubin axis that influences healthy aging and cognitive function.
摘要：
胆绿素还原酶A（BVRA）是一种多功能酶，在生理氧化还原稳态中具有多种重要作用。经典的,众所周知，BVRA将血红素代谢物胆绿素转化为胆红素，它在外周和大脑中都是一种有效的抗氧化剂。然而,此外，BVRA还参与大脑中许多保护认知的神经保护信号级联反应。这里,我们回顾了BVRA和胆红素在大脑中的神经保护作用，它们共同构成影响健康衰老和认知功能的BVRA/胆红素轴。
