PDF(Pubmed)
Abstract：
BACKGROUND: Identifying predictive factors of long COVID syndrome (LCS) is essential to preventing and managing this condition. We investigated the prevalence, symptoms, and risk factors of LCS in a cohort of Italian children and adolescents.
METHODS: We carried out a cross-sectional survey on demographic characteristics and clinical data related to COVID-19 phase and LCS in a cohort of children and adolescents, sending a questionnaire by using the PEDIATOTEM platform.
RESULTS: The prevalence of LCS was 25% (99/396). The most frequent symptoms of LCS included nasal congestion, diarrhea, headache, and fatigue. We found no association between demographic data (gender, age, and ethnicity) and LCS. Additionally, we showed that patients with concurrent allergic rhinitis, atopic dermatitis, respiratory disease, gastrointestinal disease, and rheumatologic disease had a higher risk of LCS than patients without those comorbidities. Patients experiencing fatigue, muscle, and abdominal pain in COVID-19 showed a higher risk of LCS than patients complaining of other symptoms. We found no association between vaccination and LCS.
CONCLUSIONS: Specific comorbidities or symptoms during acute illness were identified as being risk factors for LCS. Understanding which are the risk factors for LCS could yield a clearer picture of its pathogenesis.
METHODS: We carried out a cross-sectional survey on demographic characteristics and clinical data related to COVID-19 phase and LCS in a cohort of children and adolescents, sending a questionnaire by using the PEDIATOTEM platform.
RESULTS: The prevalence of LCS was 25% (99/396). The most frequent symptoms of LCS included nasal congestion, diarrhea, headache, and fatigue. We found no association between demographic data (gender, age, and ethnicity) and LCS. Additionally, we showed that patients with concurrent allergic rhinitis, atopic dermatitis, respiratory disease, gastrointestinal disease, and rheumatologic disease had a higher risk of LCS than patients without those comorbidities. Patients experiencing fatigue, muscle, and abdominal pain in COVID-19 showed a higher risk of LCS than patients complaining of other symptoms. We found no association between vaccination and LCS.
CONCLUSIONS: Specific comorbidities or symptoms during acute illness were identified as being risk factors for LCS. Understanding which are the risk factors for LCS could yield a clearer picture of its pathogenesis.
摘要：
背景：确定长COVID综合征（LCS）的预测因素对于预防和控制这种情况至关重要。我们调查了患病率，症状,以及意大利儿童和青少年队列中LCS的危险因素。
方法：我们对儿童和青少年队列中与COVID-19期和LCS相关的人口统计学特征和临床数据进行了横断面调查，使用PEDIATOTEM平台发送问卷。
结果：LCS的患病率为25％（99/396）。LCS最常见的症状包括鼻塞，腹泻,头痛,和疲劳。我们发现人口统计数据(性别，年龄,和种族）和LCS。此外,我们发现并发过敏性鼻炎的患者,特应性皮炎,呼吸道疾病,胃肠道疾病,和风湿性疾病相比没有这些合并症的患者有更高的LCS风险.患者出现疲劳,肌肉，与抱怨其他症状的患者相比，COVID-19的腹痛显示出更高的LCS风险。我们发现疫苗接种和LCS之间没有关联。
结论：急性疾病期间的特定合并症或症状被确定为LCS的危险因素。了解哪些是LCS的危险因素可以更清楚地了解其发病机理。
方法：我们对儿童和青少年队列中与COVID-19期和LCS相关的人口统计学特征和临床数据进行了横断面调查，使用PEDIATOTEM平台发送问卷。
结果：LCS的患病率为25％（99/396）。LCS最常见的症状包括鼻塞，腹泻,头痛,和疲劳。我们发现人口统计数据(性别，年龄,和种族）和LCS。此外,我们发现并发过敏性鼻炎的患者,特应性皮炎,呼吸道疾病,胃肠道疾病,和风湿性疾病相比没有这些合并症的患者有更高的LCS风险.患者出现疲劳,肌肉，与抱怨其他症状的患者相比，COVID-19的腹痛显示出更高的LCS风险。我们发现疫苗接种和LCS之间没有关联。
结论：急性疾病期间的特定合并症或症状被确定为LCS的危险因素。了解哪些是LCS的危险因素可以更清楚地了解其发病机理。
