PDF(Pubmed)
Abstract：
Gastrointestinal nematodes (GINs) can be a major constraint and global challenge to the sheep industry. These nematodes infect the small intestine and abomasum of grazing sheep, causing symptoms such as weight loss, diarrhea, hypoproteinemia, and anemia, which can lead to death. The use of anthelmintics to treat infected animals has led to GIN resistance, and excessive use of these drugs has resulted in residue traced in food and the environment. Resistance to GINs can be measured using multiple traits, including fecal egg count (FEC), Faffa Malan Chart scores, hematocrit, packed cell volume, eosinophilia, immunoglobulin (Ig), and dagginess scores. Genetic variation among animals exists, and understanding these differences can help identify genomic regions associated with resistance to GINs in sheep. Genes playing important roles in the immune system were identified in several studies in this review, such as the CFI and MUC15 genes. Results from several studies showed overlapping quantitative trait loci (QTLs) associated with multiple traits measuring resistance to GINs, mainly FEC. The discovery of genomic regions, positional candidate genes, and QTLs associated with resistance to GINs can help increase and accelerate genetic gains in sheep breeding programs and reveal the genetic basis and biological mechanisms underlying this trait.
摘要：
胃肠道线虫（GINs）可能是养羊业的主要制约因素和全球性挑战。这些线虫感染放牧绵羊的小肠和皱胃，导致体重减轻等症状，腹泻,低蛋白血症,贫血,会导致死亡.使用驱虫药治疗感染的动物导致了GIN耐药性，过度使用这些药物会导致食物和环境中的残留物。对GINs的抗性可以使用多个性状来测量，包括粪便卵数（FEC），FaffaMalan图表得分，血细胞比容,细胞体积,嗜酸性粒细胞增多,免疫球蛋白(Ig),和迟钝的分数。动物之间存在遗传变异，了解这些差异可以帮助识别与绵羊GINs抗性相关的基因组区域。在免疫系统中发挥重要作用的基因在这篇综述中的几个研究中被发现，例如CFI和MUC15基因。几项研究的结果表明，与多个性状相关的重叠数量性状位点（QTL）测量对GINs的抗性，主要是FEC。基因组区域的发现，位置候选基因，与GINs抗性相关的QTL可以帮助增加和加速绵羊育种计划中的遗传增益，并揭示该性状的遗传基础和生物学机制。
