PDF(Pubmed)
Abstract：
Clostridioides difficile is an important pathogen for humans with a lead in nosocomial infection, but it is also more and more common in communities. Our knowledge of the pathology has historically been focused on the toxins produced by the bacteria that remain its major virulence factors. But the dysbiosis of the intestinal microbiota creating the conditions for the colonization appears to be fundamental for our understanding of the disease. Colonization implies several steps for the bacteria that do or do not use their capacity of motility with the synthesis of flagella. In this review, we focus on the current understanding of different topics on the C. difficile flagellum, ranging from its genetic organization to the vaccinal interest in it.
摘要：
艰难梭菌是导致医院感染的人类的重要病原体，但在社区中也越来越普遍。历史上，我们对病理学的了解一直集中在细菌产生的毒素上，这些毒素仍然是其主要毒力因子。但是，肠道微生物群的生态失调为定殖创造条件似乎是我们理解这种疾病的基础。定殖意味着细菌的几个步骤，这些细菌利用或不利用鞭毛的运动能力。在这次审查中,我们专注于当前对艰难梭菌鞭毛不同主题的理解，从它的遗传组织到它的疫苗兴趣。
