PDF(Pubmed)
Abstract：
Atherosclerosis, which currently contributes to 31% of deaths globally, is of critical cardiovascular concern. Current diagnostic tools and biomarkers are limited, emphasizing the need for early detection. Lifestyle modifications and medications form the basis of treatment, and emerging therapies such as photodynamic therapy are being developed. Photodynamic therapy involves a photosensitizer selectively targeting components of atherosclerotic plaques. When activated by specific light wavelengths, it induces localized oxidative stress aiming to stabilize plaques and reduce inflammation. The key advantage lies in its selective targeting, sparing healthy tissues. While preclinical studies are encouraging, ongoing research and clinical trials are crucial for optimizing protocols and ensuring long-term safety and efficacy. The potential combination with other therapies makes photodynamic therapy a versatile and promising avenue for addressing atherosclerosis and associated cardiovascular disease. The investigations underscore the possibility of utilizing photodynamic therapy as a valuable treatment choice for atherosclerosis. As advancements in research continue, photodynamic therapy might become more seamlessly incorporated into clinical approaches for managing atherosclerosis, providing a blend of efficacy and limited invasiveness.
摘要：
动脉粥样硬化,目前造成全球31%的死亡，是严重的心血管问题。目前的诊断工具和生物标志物是有限的，强调早期检测的必要性。生活方式的改变和药物构成了治疗的基础，光动力疗法等新兴疗法正在开发中。光动力疗法涉及选择性靶向动脉粥样硬化斑块成分的光敏剂。当被特定的光波长激活时，它诱导局部氧化应激，旨在稳定斑块和减少炎症。关键优势在于它的选择性瞄准，保留健康的组织。虽然临床前研究令人鼓舞，正在进行的研究和临床试验对于优化方案和确保长期安全性和有效性至关重要.与其他疗法的潜在组合使光动力疗法成为解决动脉粥样硬化和相关心血管疾病的通用且有希望的途径。研究强调了利用光动力疗法作为动脉粥样硬化的有价值的治疗选择的可能性。随着研究的进展，光动力疗法可能会更无缝地整合到管理动脉粥样硬化的临床方法中，提供功效和有限侵入性的混合。
