METHODS: In this study, retrospective data from antenatal women who underwent fetal MRI between January 2014 and July 2023 at Rush University Medical Center were evaluated for CCA and classified based on structural morphology. Patients were further assessed for associated neurological and non-neurological anomalies.
RESULTS: The most frequent class of CCA was complete agenesis (79.1%), followed by hypoplasia (12.5%), dysplasia (4.2%), and hypoplasia with dysplasia (4.2%). Among them, 17% had isolated CCA, while the majority (83%) had complex forms of CCA associated with other CNS and non-CNS anomalies. Out of the complex CCA cases, 58% were associated with other CNS anomalies, while 8% were associated with non-CNS anomalies. 17% of cases had both.
CONCLUSIONS: The use of fetal MRI is valuable in the classification of abnormalities of the corpus callosum after the confirmation of a suspected diagnosis on prenatal ultrasound. This technique is an invaluable method for distinguishing between isolated and complex forms of CCA, especially in cases of apparent isolated CCA. The use of diffusion-weighted imaging or diffusion tensor imaging in fetal neuroimaging is expected to provide further insights into white matter abnormalities in fetuses diagnosed with CCA in the future.
方法:在本研究中,对2014年1月至2023年7月在拉什大学医学中心接受胎儿MRI检查的产前妇女的回顾性数据进行CCA评估,并根据结构形态进行分类.进一步评估患者的相关神经和非神经异常。
结果:最常见的CCA类别是完全发育不良(79.1%),其次是发育不全(12.5%),发育不良(4.2%),发育不全伴发育不良(4.2%)。其中,17%有孤立的CCA,而大多数(83%)具有与其他CNS和非CNS异常相关的复杂形式的CCA。在复杂的CCA案例中,58%与其他中枢神经系统异常有关,而8%与非CNS异常相关。17%的病例两者兼有。
结论:在产前超声检查确认疑似诊断后,使用胎儿MRI对call体异常的分类很有价值。该技术是区分孤立和复杂形式的CCA的宝贵方法,特别是在明显孤立的CCA的情况下。在胎儿神经成像中使用弥散加权成像或弥散张量成像有望在将来提供对诊断为CCA的胎儿白质异常的进一步见解。