PDF(Pubmed)
Abstract：
Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare tumors recently characterized by the presence of both neuroendocrine and non-neuroendocrine components within the same tumor tissue. Although MiNEN found their place in the WHO classification for various organs, this composite tumor in the head and neck region remains exceptionally rare. We present a case of primary oral MiNEN in a 64-year-old male located on the left side of lower gingiva. Biopsy raised suspicion of neuroendocrine carcinoma (NEC) and the patient underwent partial mandibulectomy. The resected specimen showed two distinct components of NEC and squamous cell carcinoma (SCC) with the confirmation of immunohistochemical markers. There has been no sign of recurrence nor metastasis 6 years after the surgery. In addition, we have conducted a review of published cases with potential relevance to this entity, resulting in five cases. The diverse terminology reinforces the need for a standardized classification system of oral/head and neck MiNENs.
摘要：
混合性神经内分泌-非神经内分泌肿瘤（MiNENs）是最近罕见的肿瘤，其特征是在同一肿瘤组织中同时存在神经内分泌和非神经内分泌成分。尽管MiNEN在WHO的各种器官分类中找到了自己的位置，头颈部的这种复合肿瘤仍然非常罕见。我们介绍了一名位于下牙龈左侧的64岁男性的原发性口服MiNEN病例。活检怀疑神经内分泌癌（NEC），患者接受了部分下颌骨切除术。切除的标本显示NEC和鳞状细胞癌（SCC）两种不同的成分，并确认了免疫组织化学标记。手术后6年没有复发或转移的迹象。此外,我们已经对与该实体潜在相关的已发表案例进行了审查，导致五个案例。不同的术语加强了对口腔/头颈部MINENs的标准化分类系统的需求。
