PDF(Pubmed)
Abstract：
Amanita phalloides poisoning is a serious health problem with a mortality rate of 10-40%. Poisonings are characterized by severe liver and kidney toxicity. The effect of Amanita phalloides poisonings on hematological parameters has not been systematically evaluated thus far.
Patients with suspected Amanita phalloides poisonings were retrospectively selected from the hospital database of the University Medical Center Groningen (UMCG). Medical data-including demographics; liver, kidney, and blood parameters; treatment; and outcomes-were collected. The severity of the poisoning was scored using the poison severity score.
Twenty-eight patients were identified who were admitted to the UMCG with suspected Amanita phalloides poisoning between 1994 and 2022. A time-dependent decrease was observed for hemoglobin and hematocrit concentrations, leukocytes, and platelets. Six out of twenty-eight patients developed acute liver failure (ALF). Patients with ALF showed a higher increase in liver enzymes, international normalized ratios, and PSS compared to patients without ALF. Conversely, hemoglobin and platelet numbers were decreased even further in these patients. Three out of six patients with ALF died and one patient received a liver transplant.
Our study shows that Amanita phalloides poisonings may be associated with hematotoxicity in patients. The quantification of hematological parameters is of relevance in intoxicated patients, especially in those with ALF.
Patients with suspected Amanita phalloides poisonings were retrospectively selected from the hospital database of the University Medical Center Groningen (UMCG). Medical data-including demographics; liver, kidney, and blood parameters; treatment; and outcomes-were collected. The severity of the poisoning was scored using the poison severity score.
Twenty-eight patients were identified who were admitted to the UMCG with suspected Amanita phalloides poisoning between 1994 and 2022. A time-dependent decrease was observed for hemoglobin and hematocrit concentrations, leukocytes, and platelets. Six out of twenty-eight patients developed acute liver failure (ALF). Patients with ALF showed a higher increase in liver enzymes, international normalized ratios, and PSS compared to patients without ALF. Conversely, hemoglobin and platelet numbers were decreased even further in these patients. Three out of six patients with ALF died and one patient received a liver transplant.
Our study shows that Amanita phalloides poisonings may be associated with hematotoxicity in patients. The quantification of hematological parameters is of relevance in intoxicated patients, especially in those with ALF.
摘要：
背景：天鹅膏中毒是一个严重的健康问题，死亡率为10-40％。中毒的特征是严重的肝和肾毒性。迄今为止，尚未系统地评估天鹅膏中毒对血液学参数的影响。
方法：从格罗宁根大学医学中心（UMCG）的医院数据库中回顾性地选择了疑似天麻类毒物中毒的患者。医疗数据-包括人口统计学；肝脏，肾,和血液参数;治疗;和结果-收集。使用毒物严重程度评分对中毒的严重程度进行评分。
结果：在1994年至2022年之间，有28名患者因疑似天鹅膏菌中毒而进入UMCG。血红蛋白和血细胞比容浓度呈时间依赖性下降，白细胞,和血小板。28例患者中有6例发展为急性肝衰竭（ALF）。ALF患者显示肝酶升高较高，国际标准化比率，和PSS与没有ALF的患者相比。相反，这些患者的血红蛋白和血小板数量进一步下降.六名ALF患者中有三名死亡，一名患者接受了肝移植。
结论：我们的研究表明，石膏粉中毒可能与患者的血液毒性有关。血液学参数的量化与中毒患者相关，尤其是那些与ALF。
方法：从格罗宁根大学医学中心（UMCG）的医院数据库中回顾性地选择了疑似天麻类毒物中毒的患者。医疗数据-包括人口统计学；肝脏，肾,和血液参数;治疗;和结果-收集。使用毒物严重程度评分对中毒的严重程度进行评分。
结果：在1994年至2022年之间，有28名患者因疑似天鹅膏菌中毒而进入UMCG。血红蛋白和血细胞比容浓度呈时间依赖性下降，白细胞,和血小板。28例患者中有6例发展为急性肝衰竭（ALF）。ALF患者显示肝酶升高较高，国际标准化比率，和PSS与没有ALF的患者相比。相反，这些患者的血红蛋白和血小板数量进一步下降.六名ALF患者中有三名死亡，一名患者接受了肝移植。
结论：我们的研究表明，石膏粉中毒可能与患者的血液毒性有关。血液学参数的量化与中毒患者相关，尤其是那些与ALF。
