PDF(Pubmed)
Abstract：
Methanogenic archaea are a part of the commensal gut microbiota responsible for hydrogen sink and the efficient production of short-chain fatty acids. Dysbiosis of methanogens is suspected to play a role in pathogenesis of variety of diseases, including inflammatory bowel disease (IBD). Unlike bacteria, the diversity of archaea seems to be higher in IBD patients compared to healthy subjects, whereas the prevalence and abundance of gut methanogens declines in IBD, especially in ulcerative colitis. To date, studies focusing on methanogens in pediatric IBD are very limited; nevertheless, the preliminary results provide some evidence that methanogens may be influenced by the chronic inflammatory process in IBD. In this review, we demonstrated the development and diversity of the methanogenic community in IBD, both in adults and children.
摘要：
产甲烷古菌是共生肠道微生物群的一部分，负责氢汇和短链脂肪酸的有效生产。怀疑产甲烷菌菌群失调在多种疾病的发病机理中起作用，包括炎症性肠病（IBD）。不像细菌,与健康受试者相比，IBD患者的古菌多样性似乎更高，而肠道产甲烷菌的患病率和丰度在IBD中下降，尤其是溃疡性结肠炎。迄今为止,专注于小儿IBD产甲烷菌的研究非常有限；然而，初步结果提供了一些证据，表明产甲烷菌可能受到IBD慢性炎症过程的影响。在这次审查中,我们证明了IBD产甲烷群落的发展和多样性，无论是成人还是儿童。
