PDF(Pubmed)
Abstract：
Oral squamous cell carcinoma (OSCC) is the most common and lethal type of head and neck cancer in the world. Variable response and acquisition of resistance to traditional therapies show that it is essential to develop novel strategies that can provide better outcomes for the patient. Understanding of cellular and molecular mechanisms of cell death control has increased rapidly in recent years. Activation of cell death pathways, such as the emerging forms of non-apoptotic programmed cell death, including ferroptosis, pyroptosis, necroptosis, NETosis, parthanatos, mitoptosis and paraptosis, may represent clinically relevant novel therapeutic opportunities. This systematic review summarizes the recently described forms of cell death in OSCC, highlighting their potential for informing diagnosis, prognosis and treatment. Original studies that explored any of the selected cell deaths in OSCC were included. Electronic search, study selection, data collection and risk of bias assessment tools were realized. The literature search was carried out in four databases, and the extracted data from 79 articles were categorized and grouped by type of cell death. Ferroptosis, pyroptosis, and necroptosis represented the main forms of cell death in the selected studies, with links to cancer immunity and inflammatory responses, progression and prognosis of OSCC. Harnessing the potential of these pathways may be useful in patient-specific prognosis and individualized therapy. We provide perspectives on how these different cell death types can be integrated to develop decision tools for diagnosis, prognosis, and treatment of OSCC.
摘要：
口腔鳞状细胞癌（OSCC）是世界上最常见和最致命的头颈部癌症。对传统疗法的可变反应和抵抗的获得表明，开发可以为患者提供更好结果的新策略至关重要。近年来，对细胞死亡控制的细胞和分子机制的了解迅速增加。细胞死亡途径的激活，如非凋亡性程序性细胞死亡的新兴形式，包括铁性凋亡,焦亡,坏死,NETosis,Parthanatos,线粒体凋亡和凋亡，可能代表临床相关的新治疗机会。这篇系统的综述总结了最近描述的OSCC中细胞死亡的形式，强调他们为诊断提供信息的潜力，预后和治疗。包括探索OSCC中任何选定细胞死亡的原始研究。电子搜索,研究选择，实现了数据收集和偏差风险评估工具。在四个数据库中进行了文献检索，从79篇文章中提取的数据按细胞死亡类型进行分类和分组。Ferroptosis,焦亡,在选定的研究中，坏死是细胞死亡的主要形式，与癌症免疫和炎症反应有关，OSCC的进展和预后。利用这些途径的潜力可能对患者特异性预后和个体化治疗有用。我们提供了如何整合这些不同细胞死亡类型以开发诊断决策工具的观点。预后,OSCC的治疗。
