PDF(Pubmed)
Abstract：
In recent years, the nexus between genetics and biomechanics has garnered significant attention, elucidating the role of genomic determinants in shaping the biomechanical attributes of human joints, specifically the knee. This review seeks to provide a comprehensive exploration of the molecular basis underlying knee joint locomotor function. Leveraging advancements in genomic sequencing, we identified specific genetic markers and polymorphisms tied to key biomechanical features of the knee, such as ligament elasticity, meniscal resilience, and cartilage health. Particular attention was devoted to collagen genes like COL1A1 and COL5A1 and their influence on ligamentous strength and injury susceptibility. We further investigated the genetic underpinnings of knee osteoarthritis onset and progression, as well as the potential for personalized rehabilitation strategies tailored to an individual\'s genetic profile. We reviewed the impact of genetic factors on knee biomechanics and highlighted the importance of personalized orthopedic interventions. The results hold significant implications for injury prevention, treatment optimization, and the future of regenerative medicine, targeting not only knee joint health but joint health in general.
摘要：
近年来,遗传学和生物力学之间的联系引起了极大的关注，阐明基因组决定因素在塑造人体关节生物力学属性中的作用，特别是膝盖。本文旨在全面探索膝关节运动功能的分子基础。利用基因组测序的进步，我们确定了与膝关节关键生物力学特征相关的特定遗传标记和多态性，比如韧带弹性，半月板弹性，和软骨健康。特别注意胶原蛋白基因如COL1A1和COL5A1及其对韧带强度和损伤易感性的影响。我们进一步研究了膝骨关节炎发病和进展的遗传基础，以及针对个人遗传特征量身定制的个性化康复策略的潜力。我们回顾了遗传因素对膝关节生物力学的影响，并强调了个性化骨科干预的重要性。结果对伤害预防具有重要意义，治疗优化，以及再生医学的未来，不仅针对膝关节健康，而且针对关节健康。
