关键词: extracellular pathogens innate immune cells (ILC) intracellular pathogens

Mesh : Lymphocytes Immunity, Innate Cell Differentiation

来  源:   DOI:10.3390/cells13040335   PDF(Pubmed)

Abstract:
Over the past decade, a group of lymphocyte-like cells called innate lymphoid cells (ILCs) has gained considerable attention due to their crucial role in regulating immunity and tissue homeostasis. ILCs, lacking antigen-specific receptors, are a group of functionally differentiated effector cells that act as tissue-resident sentinels against infections. Numerous studies have elucidated the characteristics of ILC subgroups, but the mechanisms controlling protective or pathological responses to pathogens still need to be better understood. This review summarizes the functions of ILCs in the immunology of infections caused by different intracellular and extracellular pathogens and discusses their possible therapeutic potential.
摘要:
在过去的十年里,一组称为先天淋巴样细胞(ILC)的淋巴细胞样细胞由于其在调节免疫和组织稳态中的关键作用而受到了广泛关注。ILC,缺乏抗原特异性受体,是一组功能分化的效应细胞,作为组织驻留的前哨抗感染。许多研究已经阐明了ILC亚组的特征,但是控制对病原体的保护性或病理性反应的机制仍需要更好地理解。这篇综述总结了ILC在由不同细胞内和细胞外病原体引起的感染的免疫学中的功能,并讨论了它们可能的治疗潜力。
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