PDF(Pubmed)
Abstract：
Zika virus (ZIKV) and chikungunya virus (CHIKV) are arthropod-borne viruses with significant pathogenicity, posing a substantial health and economic burden on a global scale. Moreover, ZIKV-CHIKV coinfection imposes additional therapeutic challenges as there is no specific treatment for ZIKV or CHIKV infection. While a growing number of studies have documented the ZIKV-CHIKV coinfection, there is currently a lack of conclusive reports on this coinfection. Therefore, we performed a systematic review and meta-analysis to determine the true statistics of ZIKV-CHIKV coinfection in the global human population. Relevant studies were searched for in PubMed, Scopus, and Google Scholar without limitation in terms of language or publication date. A total of 33 studies containing 41,460 participants were included in this meta-analysis. The study protocol was registered with PROSPERO under the registration number CRD42020176409. The pooled prevalence and confidence intervals of ZIKV-CHIKV coinfection were computed using a random-effects model. The study estimated a combined global prevalence rate of 1.0% [95% CI: 0.7-1.2] for the occurrence of ZIKV-CHIKV coinfection. The region of North America (Mexico, Haiti, and Nicaragua) and the country of Haiti demonstrated maximum prevalence rates of 2.8% [95% CI: 1.5-4.1] and 3.5% [95% CI: 0.2-6.8], respectively. Moreover, the prevalence of coinfection was found to be higher in the paediatric group (2.1% [95% CI: 0.0-4.2]) in comparison with the adult group (0.7% [95% CI: 0.2-1.1]). These findings suggest that the occurrence of ZIKV-CHIKV coinfection varies geographically and by age group. The results of this meta-analysis will guide future investigations seeking to understand the underlying reasons for these variations and the causes of coinfection and to develop targeted prevention and control strategies.
摘要：
寨卡病毒(ZIKV)和基孔肯雅病毒(CHIKV)是具有显著致病性的节肢动物病毒,在全球范围内构成巨大的健康和经济负担。此外，ZIKV-CHIKV共感染带来了额外的治疗挑战，因为没有针对ZIKV或CHIKV感染的特定治疗方法。虽然越来越多的研究记录了ZIKV-CHIKV共感染，目前缺乏关于这种共感染的结论性报告。因此,我们进行了系统评价和荟萃分析,以确定全球人群中ZIKV-CHIKV合并感染的真实统计数据.在PubMed中搜索了相关研究，Scopus,和谷歌学者在语言或出版日期方面没有限制。共有33项研究纳入了41,460名参与者。研究方案在PROSPERO注册，注册号为CRD42020176409。使用随机效应模型计算ZIKV-CHIKV共感染的合并患病率和置信区间。该研究估计ZIKV-CHIKV共感染的全球合并患病率为1.0％[95％CI：0.7-1.2]。北美地区（墨西哥，海地,和尼加拉瓜），海地国家的最大患病率为2.8％[95％CI：1.5-4.1]和3.5％[95％CI：0.2-6.8]，分别。此外，与成人组(0.7%[95%CI:0.2-1.1])相比,儿科组合并感染的患病率更高(2.1%[95%CI:0.0-4.2]).这些发现表明，ZIKV-CHIKV共感染的发生在地理上和年龄组之间有所不同。这项荟萃分析的结果将指导未来的调查，以寻求了解这些变化的根本原因和合并感染的原因，并制定有针对性的预防和控制策略。
