PDF(Pubmed)
Abstract：
Functional ultrasound (fUS) flow imaging provides a non-invasive method for the in vivo study of cerebral blood flow and neural activity. This study used functional flow imaging to investigate rat brain\'s response to ultrasound and colored-light stimuli. Male Long-Evan rats were exposed to direct full-field strobe flashes light and ultrasound stimulation to their retinas, while brain activity was measured using high-frequency ultrasound imaging. Our study found that light stimuli, particularly blue light, elicited strong responses in the visual cortex and lateral geniculate nucleus (LGN), as evidenced by changes in cerebral blood volume (CBV). In contrast, ultrasound stimulation elicited responses undetectable with fUS flow imaging, although these were observable when directly measuring the brain\'s electrical signals. These findings suggest that fUS flow imaging can effectively differentiate neural responses to visual stimuli, with potential applications in understanding visual processing and developing new diagnostic tools.
摘要：
功能超声（fUS）流成像为体内研究脑血流和神经活动提供了一种非侵入性方法。这项研究使用功能流成像来研究大鼠大脑对超声和彩色光刺激的反应。雄性长埃文大鼠暴露于直接的全场频闪闪光和对其视网膜的超声刺激，而使用高频超声成像测量大脑活动。我们的研究发现光刺激，尤其是蓝光，在视觉皮层和外侧膝状核（LGN）中引起强烈反应，脑血容量（CBV）的变化证明了这一点。相比之下,超声刺激引起的反应无法检测到的fus流成像，尽管这些在直接测量大脑的电信号时是可以观察到的。这些发现表明，fUS流成像可以有效区分神经对视觉刺激的反应，在理解视觉处理和开发新的诊断工具方面具有潜在的应用。
