PDF(Pubmed)
Abstract：
Antimicrobial resistance (AMR) is a complex and somewhat unpredictable phenomenon. Historically, the utilization of avoparcin in intensive farming during the latter part of the previous century led to the development of resistance to vancomycin, a crucial antibiotic in human medicine with life-saving properties. Currently, in the European Union, there is a growing reliance on the ionophore antibiotic monensin (MON), which acts both as a coccidiostat in poultry farming and as a preventative measure against ketosis in lactating cows. Although many researchers claim that MON does not induce cross-resistance to antibiotics of clinical relevance in human medicine, some conflicting reports exist. The numerous applications of MON in livestock farming and the consequent dissemination of the compound and its metabolites in the environment require further investigation to definitively ascertain whether MON represents a potential vector for the propagation of AMR. It is imperative to emphasize that antibiotics cannot substitute sound animal husbandry practices or tailored dietary regimens in line with the different production cycles of livestock. Consequently, a rigorous evaluation is indispensable to assess whether the economic benefits associated with MON usage justify its employment, also considering its local and global environmental ramifications and the potential risk of instigating AMR with increased costs for its control.
摘要：
抗菌素耐药性（AMR）是一种复杂且有些不可预测的现象。历史上,在上世纪下半叶，在集约化农业中利用阿伏霉素导致了对万古霉素的耐药性的发展，在人类医学中具有挽救生命的重要抗生素。目前,在欧盟，对离子载体抗生素莫能菌素(MON)的依赖越来越大，它既是家禽养殖中的抗球虫药，又是预防泌乳奶牛酮症的预防措施。尽管许多研究人员声称MON不会在人类医学中引起对临床相关抗生素的交叉耐药性，存在一些相互矛盾的报告。MON在畜牧业中的众多应用以及该化合物及其代谢物在环境中的传播需要进一步研究，以最终确定MON是否代表AMR传播的潜在载体。必须强调，抗生素不能代替合理的畜牧业做法或根据牲畜的不同生产周期定制的饮食方案。因此,严格的评估对于评估与MON使用相关的经济利益是否证明其就业是必不可少的，还考虑了其对当地和全球环境的影响，以及煽动AMR的潜在风险，并增加了其控制成本。
