PDF(Pubmed)
Abstract：
Necrotizing enterocolitis (NEC) is a destructive gastrointestinal disease primarily affecting preterm babies. Despite advancements in neonatal care, NEC remains a significant cause of morbidity and mortality in neonatal intensive care units worldwide and the etiology of NEC is still unclear. Risk factors for NEC include prematurity, very low birth weight, feeding with formula, intestinal dysbiosis and bacterial infection. A review of the literature would suggest that supplementation of prebiotics and probiotics prevents NEC by altering the immune responses. Innate T cells, a highly conserved subpopulation of T cells that responds quickly to stimulation, develops differently from conventional T cells in neonates. This review aims to provide a succinct overview of innate T cells in neonates, encompassing their phenotypic characteristics, functional roles, likely involvement in the pathogenesis of NEC, and potential therapeutic implications.
摘要：
坏死性小肠结肠炎（NEC）是一种主要影响早产儿的破坏性胃肠道疾病。尽管新生儿护理取得了进步，NEC仍然是全球新生儿重症监护病房发病率和死亡率的重要原因，NEC的病因仍不清楚。NEC的风险因素包括早产，出生体重很低,用配方喂养，肠道菌群失调和细菌感染。文献综述表明，补充益生元和益生菌可通过改变免疫反应来预防NEC。先天T细胞，对刺激反应迅速的高度保守的T细胞亚群，与新生儿的常规T细胞不同。这篇综述旨在提供新生儿先天性T细胞的简要概述。包括它们的表型特征，功能角色，可能参与NEC的发病机制，和潜在的治疗影响。
