PDF(Pubmed)
Abstract：
Primary pulmonary hyalinizing clear cell carcinoma (HCCC) is a very rare lung tumor that accounts for less than 0.09% of all primary lung tumors and has no specific epidemiology. The correct diagnosis requires imaging, laboratory, pathological, immunohistochemical, and molecular examination. The most typical feature of pulmonary HCCC is the clear cell component with clear stroma. In addition, the fusion gene EWSR1::ATF1 due to t(12;22)(q13;q12) is essential for the pathological diagnosis of pulmonary HCCC. The main treatment for pulmonary HCCC is surgery. This review focus on the pathological features, immunohistochemical examination, mutation analysis and treatment of pulmonary HCCC.
摘要：
原发性肺透明化透明细胞癌（HCCC）是一种非常罕见的肺肿瘤，占所有原发性肺肿瘤的不到0.09％，并且没有特异性流行病学。正确的诊断需要成像,实验室,病态,免疫组织化学，和分子检查。肺HCCC最典型的特征是细胞成分透明，基质透明。此外,由于t（12;22）（q13;q12）引起的融合基因EWSR1::ATF1对于肺HCCC的病理诊断至关重要。肺HCCC的主要治疗方法是手术。这篇综述集中在病理特征，免疫组织化学检查，肺HCCC突变分析及治疗.
