PDF(Pubmed)
Abstract：
Diabetic retinopathy (DR) is a condition that causes swelling of the blood vessels of the retina and leaks blood and fluids. It is the most severe form of diabetic eye disease. It causes vision loss in its advanced stage. Diabetic retinopathy is responsible for causing 26% of blindness. Very insufficient therapies are accessible for the treatment of DR. As compared to the conventional therapies, there should be enhanced research on the controlled release, shorter duration, and cost-effective therapy of diabetic retinopathy. The expansion of advanced nanocarriers-based drug delivery systems has been now employed to exploit as well as regulate the transport of many therapeutic agents to target sites via the increase in penetration or the extension of the duration of contact employing production by enclosing as well as distributing tiny molecules in nanostructured formulation. Various polymers have been utilized for the manufacturing of these nanostructured formulations. Chitosan possesses incredible biological and chemical properties, that have led to its extensive use in pharmaceutical and biomedical applications. Chitosan has been used in many studies because of its enhanced mucoadhesiveness and non-toxicity. Multiple studies have used chitosan as the best candidate for manufacturing nanocarriers and treating diabetic retinopathy. Numerous nanocarriers have been formulated by using chitosan such as nanostructured lipid carriers, solid lipid nanoparticles, liposomes, and dendrimers for treating diabetic retinopathy. This current review elaborates on the recent advancements of chitosan as a promising approach for the manufacturing of nanocarriers that can be used for treating diabetic retinopathy.
摘要：
糖尿病性视网膜病变（DR）是一种导致视网膜血管肿胀并泄漏血液和液体的疾病。它是糖尿病性眼病的最严重形式。它在晚期导致视力丧失。糖尿病性视网膜病变是造成26％失明的原因。用于治疗DR的疗法非常不足。与传统疗法相比，应该加强对控释的研究，持续时间较短，和糖尿病视网膜病变的经济有效的治疗。基于先进纳米载体的药物递送系统的扩展现已用于通过增加渗透或延长接触持续时间来利用和调节许多治疗剂向靶位点的运输,所述接触持续时间采用通过包封以及分布在纳米结构制剂中的微小分子的生产。各种聚合物已用于制造这些纳米结构制剂。壳聚糖具有令人难以置信的生物和化学性质,这导致了它在制药和生物医学应用中的广泛使用。壳聚糖由于其增强的粘膜粘附性和无毒性而被用于许多研究中。多项研究已经使用壳聚糖作为制造纳米载体和治疗糖尿病性视网膜病变的最佳候选物。已经通过使用壳聚糖如纳米结构脂质载体配制了许多纳米载体,固体脂质纳米粒，脂质体，和用于治疗糖尿病性视网膜病变的树枝状聚合物。本综述阐述了壳聚糖作为制造可用于治疗糖尿病性视网膜病变的纳米载体的有希望的方法的最新进展。
