Abstract：
Eight previously undescribed diterpenoids, along with eleven previously reported analogues, were obtained from the supercritical CO2 extracts of Torreya grandis aril. The structures of these compounds were elucidated based on HRESIMS, NMR, ECD, and single-crystal X-ray diffraction data. In the MTT assay, compound 18 exhibited significant inhibitory effects on two human colon cancer cell lines, HT-29 and HCT 116 cells, with IC50 values of 7.37 μM and 6.55 μM, respectively. It was found that compound 18 induced apoptosis and significantly inhibited the migration of HCT 116 colon cancer cells in a concentration-dependent manner.
摘要：
八种以前没有描述的二萜，连同先前报道的11种类似物，是从香菇种皮的超临界CO2提取物中获得的。基于HRESIMS阐明了这些化合物的结构，NMR,ECD,和单晶X射线衍射数据。在MTT试验中,化合物18对两种人结肠癌细胞系表现出显著的抑制作用，HT-29和HCT116细胞，IC50值为7.37μM和6.55μM，分别。发现化合物18以浓度依赖性方式诱导HCT116结肠癌细胞凋亡并显著抑制其迁移。
