Abstract：
OBJECTIVE: We aimed to evaluate the association of occupational noise with metabolic syndrome (MetS) and its components, and to assess the potential role of miRNAs in occupational noise-associated MetS.
METHODS: A total of 854 participants were enrolled in our study. Cumulative noise exposure (CNE) was estimated in conjunction with workplace noise test records and research participants\' employment histories. Logistic regression models adjusted for potential confounders were used to assess the association of CNE and miRNAs with MetS and its components.
RESULTS: We observed linear positive dose-response associations between occupational noise exposure and the prevalence of MetS (OR: 1.031; 95 % CI: 1.008, 1.055). And linear and nonlinear relationship were also found for the association of occupational noise exposure with high blood pressure (OR: 1.024; 95 % CI: 1.007, 1.041) and reduced high-density lipoprotein (OR: 1.051; 95 % CI: 1.031, 1.072), respectively. MiR-200a-3p, miR-92a-3p and miR-21-5p were inversely associated with CNE, or the prevalence of MetS and its components (all P < 0.05). However, we did not find any statistically significant mediation effect of miRNAs in the associations of CNE with MetS. Furthermore, the prevalence of bilateral hearing loss in high-frequency increased (OR: 1.036; 95 % CI: 1.008, 1.067) with CNE level rising, and participants with bilateral hearing loss in high-frequency had a significantly higher risk of MetS (OR: 1.727; 95 % CI: 1.048, 2.819).
CONCLUSIONS: Our study suggests that occupational noise exposure is associated with MetS and its components, and the role of miRNAs in noise-induced increasing MetS risk needs to be confirmed in future studies.
METHODS: A total of 854 participants were enrolled in our study. Cumulative noise exposure (CNE) was estimated in conjunction with workplace noise test records and research participants\' employment histories. Logistic regression models adjusted for potential confounders were used to assess the association of CNE and miRNAs with MetS and its components.
RESULTS: We observed linear positive dose-response associations between occupational noise exposure and the prevalence of MetS (OR: 1.031; 95 % CI: 1.008, 1.055). And linear and nonlinear relationship were also found for the association of occupational noise exposure with high blood pressure (OR: 1.024; 95 % CI: 1.007, 1.041) and reduced high-density lipoprotein (OR: 1.051; 95 % CI: 1.031, 1.072), respectively. MiR-200a-3p, miR-92a-3p and miR-21-5p were inversely associated with CNE, or the prevalence of MetS and its components (all P < 0.05). However, we did not find any statistically significant mediation effect of miRNAs in the associations of CNE with MetS. Furthermore, the prevalence of bilateral hearing loss in high-frequency increased (OR: 1.036; 95 % CI: 1.008, 1.067) with CNE level rising, and participants with bilateral hearing loss in high-frequency had a significantly higher risk of MetS (OR: 1.727; 95 % CI: 1.048, 2.819).
CONCLUSIONS: Our study suggests that occupational noise exposure is associated with MetS and its components, and the role of miRNAs in noise-induced increasing MetS risk needs to be confirmed in future studies.
摘要：
目的：我们旨在评估职业噪声与代谢综合征（MetS）及其成分的关联，并评估miRNAs在职业性噪声相关MetS中的潜在作用。
方法：共有854名参与者参加了我们的研究。累积噪声暴露量（CNE）是结合工作场所噪声测试记录和研究参与者的就业历史进行估计的。使用针对潜在混杂因素调整的Logistic回归模型来评估CNE和miRNA与MetS及其组分的关联。
结果：我们观察到职业性噪声暴露与MetS患病率之间的线性正剂量反应关联（OR：1.031；95％CI：1.008，1.055）。职业噪声暴露与高血压（OR：1.024；95％CI：1.007，1.041）和高密度脂蛋白降低（OR：1.051；95％CI：1.031，1.072）之间也存在线性和非线性关系。分别。MiR-200a-3p,miR-92a-3p和miR-21-5p与CNE呈负相关，或MetS及其组成部分的患病率（均P<0.05）。然而,在CNE与MetS的关联中,我们没有发现任何统计学上显著的miRNA介导作用.此外，随着CNE水平的升高，高频双侧听力损失的患病率增加（OR：1.036；95％CI：1.008，1.067），且双侧听力损失较高频率的参与者患MetS的风险显著较高(OR:1.727;95%CI:1.048,2.819).
结论：我们的研究表明，职业噪声暴露与MetS及其成分有关，miRNAs在噪声诱导的MetS风险增加中的作用需要在未来的研究中得到证实。
方法：共有854名参与者参加了我们的研究。累积噪声暴露量（CNE）是结合工作场所噪声测试记录和研究参与者的就业历史进行估计的。使用针对潜在混杂因素调整的Logistic回归模型来评估CNE和miRNA与MetS及其组分的关联。
结果：我们观察到职业性噪声暴露与MetS患病率之间的线性正剂量反应关联（OR：1.031；95％CI：1.008，1.055）。职业噪声暴露与高血压（OR：1.024；95％CI：1.007，1.041）和高密度脂蛋白降低（OR：1.051；95％CI：1.031，1.072）之间也存在线性和非线性关系。分别。MiR-200a-3p,miR-92a-3p和miR-21-5p与CNE呈负相关，或MetS及其组成部分的患病率（均P<0.05）。然而,在CNE与MetS的关联中,我们没有发现任何统计学上显著的miRNA介导作用.此外，随着CNE水平的升高，高频双侧听力损失的患病率增加（OR：1.036；95％CI：1.008，1.067），且双侧听力损失较高频率的参与者患MetS的风险显著较高(OR:1.727;95%CI:1.048,2.819).
结论：我们的研究表明，职业噪声暴露与MetS及其成分有关，miRNAs在噪声诱导的MetS风险增加中的作用需要在未来的研究中得到证实。
