协同双药治疗特异性靶向发生在 p53 缺陷的结直肠癌和胰腺癌中的 DNA 修复失调。
关键词: 5-fluorodeoxyuridine DNA damage PARP inhibitor TAS102 colorectal cancer pancreatic cancer patient-derived xenograft poly(ADP-ribose) polymerase trifluorothymidine
Mesh : Humans Tumor Suppressor Protein p53 / genetics Poly(ADP-ribose) Polymerase Inhibitors / pharmacology therapeutic use DNA Repair Poly(ADP-ribose) Polymerases / genetics metabolism Pancreatic Neoplasms / drug therapy genetics DNA / therapeutic use Thymidine / therapeutic use Colorectal Neoplasms / drug therapy genetics
来 源:
DOI:10.1016/j.xcrm.2024.101434
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