Abstract：
OBJECTIVE: This study aimed to analyze the cardiac effects of hyperandrogenism in premature adrenarche (PA) and evaluate the risk of arrhythmia development.
METHODS: Fifty patients with PA and 50 healthy children from a pediatric endocrinology outpatient clinic were included in the study. The patients underwent echocardiography and electrocardiographic evaluations. Conventional echocardiography, tissue Doppler echocardiography, repolarization time, and repolarization dispersion time were evaluated.
RESULTS: The median age in the PA and control groups was 7.91 years (5.83-9.25), 8.08 years (5.75-9.33), respectively. Thirty percent of patients in the PA group were male. While mitral early diastolic velocity deceleration time (DT), isovolumetric relaxation time (IRT), and E/e\' ratio were significantly higher in the PA group than in the control group, mitral lateral annulus tissue Doppler early diastolic velocity was significantly lower (p=0.0001, 0.0001, 0.003, 0.0001). While P wave dispersion (PWD), Tpe, and QT-dispersion (QT-d) values were significantly higher in the PA group than in the control group, the P minimum value was significantly lower in the PA group (p=0.0001, 0.02, 0.004, and 0.0001, respectively).
CONCLUSIONS: Early subclinical diastolic dysfunction was observed in the PA group. There was an increased risk of atrial arrhythmia with PWD and an increased risk of ventricular arrhythmia with increased Tpe and QT-d. There was a correlation between testosterone levels and diastolic function parameters. The increased risk of atrial arrhythmia is closely related to diastolic function.
METHODS: Fifty patients with PA and 50 healthy children from a pediatric endocrinology outpatient clinic were included in the study. The patients underwent echocardiography and electrocardiographic evaluations. Conventional echocardiography, tissue Doppler echocardiography, repolarization time, and repolarization dispersion time were evaluated.
RESULTS: The median age in the PA and control groups was 7.91 years (5.83-9.25), 8.08 years (5.75-9.33), respectively. Thirty percent of patients in the PA group were male. While mitral early diastolic velocity deceleration time (DT), isovolumetric relaxation time (IRT), and E/e\' ratio were significantly higher in the PA group than in the control group, mitral lateral annulus tissue Doppler early diastolic velocity was significantly lower (p=0.0001, 0.0001, 0.003, 0.0001). While P wave dispersion (PWD), Tpe, and QT-dispersion (QT-d) values were significantly higher in the PA group than in the control group, the P minimum value was significantly lower in the PA group (p=0.0001, 0.02, 0.004, and 0.0001, respectively).
CONCLUSIONS: Early subclinical diastolic dysfunction was observed in the PA group. There was an increased risk of atrial arrhythmia with PWD and an increased risk of ventricular arrhythmia with increased Tpe and QT-d. There was a correlation between testosterone levels and diastolic function parameters. The increased risk of atrial arrhythmia is closely related to diastolic function.
摘要：
目的：本研究旨在分析高雄激素血症对早熟肾上腺素（PA）的心脏影响，并评估心律失常发展的风险。
方法：本研究包括50名PA患者和50名来自儿科内分泌科门诊的健康儿童。患者接受超声心动图和心电图评估。常规超声心动图,组织多普勒超声心动图，复极化时间，和复极化色散时间进行了评估。
结果：PA组和对照组的中位年龄为7.91岁（5.83-9.25），8.08年（5.75-9.33），分别。PA组中30%的患者是男性。而二尖瓣舒张早期速度减速时间(DT),等体积弛豫时间（IRT），PA组E/e比值显著高于对照组,二尖瓣外侧环组织多普勒早期舒张速度明显降低(p=0.0001、0.0001、0.003、0.0001)。而P波色散(PWD),Tpe,和QT离散度(QT-d)值均显著高于对照组,PA组P最小值显著较低(p分别为0.0001,0.02,0.004和0.0001).
结论：在PA组中观察到早期亚临床舒张功能障碍。PWD的房性心律失常风险增加，而Tpe和QT-d增加的室性心律失常风险增加。睾酮水平与舒张功能参数之间存在相关性。房性心律失常的风险增加与舒张功能密切相关。
方法：本研究包括50名PA患者和50名来自儿科内分泌科门诊的健康儿童。患者接受超声心动图和心电图评估。常规超声心动图,组织多普勒超声心动图，复极化时间，和复极化色散时间进行了评估。
结果：PA组和对照组的中位年龄为7.91岁（5.83-9.25），8.08年（5.75-9.33），分别。PA组中30%的患者是男性。而二尖瓣舒张早期速度减速时间(DT),等体积弛豫时间（IRT），PA组E/e比值显著高于对照组,二尖瓣外侧环组织多普勒早期舒张速度明显降低(p=0.0001、0.0001、0.003、0.0001)。而P波色散(PWD),Tpe,和QT离散度(QT-d)值均显著高于对照组,PA组P最小值显著较低(p分别为0.0001,0.02,0.004和0.0001).
结论：在PA组中观察到早期亚临床舒张功能障碍。PWD的房性心律失常风险增加，而Tpe和QT-d增加的室性心律失常风险增加。睾酮水平与舒张功能参数之间存在相关性。房性心律失常的风险增加与舒张功能密切相关。
