PDF(Pubmed)
Abstract：
Autism spectrum disorder (ASD) is a neurodevelopmental condition that exhibits a widely heterogeneous range of social and cognitive symptoms. This feature has challenged a broad comprehension of this neurodevelopmental disorder and therapeutic efforts to address its difficulties. Current therapeutic strategies have focused primarily on treating behavioral symptoms rather than on brain psychophysiology. During the past years, the emergence of non-invasive brain stimulation techniques (NIBS) has opened alternatives to the design of potential combined treatments focused on the neurophysiopathology of neuropsychiatric disorders like ASD. Such interventions require identifying the key brain mechanisms underlying the symptomatology and cognitive features. Evidence has shown alterations in oscillatory features of the neural ensembles associated with cognitive functions in ASD. In this line, we elaborated a systematic revision of the evidence of alterations in brain oscillations that underlie key cognitive processes that have been shown to be affected in ASD during childhood and adolescence, namely, social cognition, attention, working memory, inhibitory control, and cognitive flexibility. This knowledge could contribute to developing therapies based on NIBS to improve these processes in populations with ASD.
摘要：
自闭症谱系障碍（ASD）是一种神经发育状况，表现出广泛的社会和认知症状。这一特征挑战了对这种神经发育障碍的广泛理解和解决其困难的治疗努力。目前的治疗策略主要集中在治疗行为症状，而不是大脑心理生理学。在过去的几年里,非侵入性脑刺激技术(NIBS)的出现为设计针对ASD等神经精神疾病的神经生理学病理学的潜在联合治疗方案开辟了新的选择.这种干预需要确定症状学和认知特征的关键脑机制。有证据表明，与ASD认知功能相关的神经集合的振荡特征发生了变化。在这行,我们对大脑振荡改变的证据进行了系统的修订，这些证据是关键认知过程的基础，这些过程已被证明在儿童和青春期受到ASD的影响，即,社会认知，注意,工作记忆,抑制控制，和认知灵活性。这些知识可能有助于开发基于NIBS的疗法，以改善ASD人群的这些过程。
