PDF(Pubmed)
Abstract：
BACKGROUND Hospital-acquired infections negatively impact the health of inpatients and are highly costly to treat. Oral care reduces the microorganism number in the mouth and lungs and is essential in preventing postoperative oral inflammation, lung infection, and other complications. This study was designed to determine the effects of oral care with glutamine on oral health, oral flora, and incidence of pneumonia in patients after neurosurgery. MATERIAL AND METHODS This was a parallel, double-blind, randomized trial. Patients admitted to the Neurosurgery Department of the hospital from July to October 2021 were selected. Three hundred patients who met the inclusion criteria were randomized into 3 groups. The control group (n=100) received oral care with routine oral nursing methods with saline, whereas the experimental group (n=100) received oral care with 5% glutamine. A compound chlorhexidine group (n=100) was set as a positive control. All patients, care providers, and investigators were blinded to the group assignment. The incidence of local debris, oral mucositis, halitosis, dryness, oral mucositis disorders, and oral flora types were collected and analyzed in all groups. RESULTS The incidence of local debris, oral mucositis, halitosis, dryness, and other oral mucositis disorders in the glutamine oral care group was significantly decreased, compared with that of the control group. Oral flora types in the glutamine and chlorhexidine groups were significantly reduced. CONCLUSIONS Oral care with 5% glutamine after neurosurgery is associated with a lower incidence of oral disorders and pneumonia, and a significant reduction in oral flora.
摘要：
背景技术医院获得性感染对住院患者的健康产生负面影响,并且治疗成本很高。口腔护理可减少口腔和肺部的微生物数量，对预防术后口腔炎症至关重要。肺部感染,和其他并发症。本研究旨在确定谷氨酰胺口腔护理对口腔健康的影响，口腔菌群,神经外科术后患者的肺炎发生率。材料和方法这是一个平行的，双盲,随机试验。选择了2021年7月至10月入住医院神经外科的患者。将300名符合纳入标准的患者随机分为3组。对照组(n=100)采用生理盐水口腔常规护理方法进行口腔护理,而实验组（n=100）接受5％谷氨酰胺的口腔护理。将化合物氯己定组(n=100)设置为阳性对照。所有患者,护理提供者，研究人员对小组分配视而不见.局部碎片的发生率，口腔粘膜炎，口臭,干燥度,口腔粘膜炎疾病，收集并分析各组的口腔菌群类型。结果局部碎片的发生率，口腔粘膜炎，口臭,干燥度,谷氨酰胺口腔护理组的其他口腔粘膜炎疾病明显减少，与对照组相比。谷氨酰胺和氯己定组的口腔菌群类型显着减少。结论神经外科术后使用5％谷氨酰胺的口腔护理与较低的口腔疾病和肺炎发生率相关。和口腔菌群的显著减少。
