Abstract：
Drug addiction is associated with significant health risks, including cardiovascular complications, cancer, and mental disorders. Illicit drugs, such as cannabinoids and opioids, including prescription medications, are widely consumed and have profound health consequences. Understanding the health effects of the toxic elements in these substances is critical for overdose prevention and effective recovery strategies. This study aimed to determine toxic elements, including arsenic (As), cadmium (Cd), mercury (Hg), and nickel (Ni), in cannabinoid and opioid drugs and in biological samples (whole blood, scalp hair, and serum) from 311 male drug abuse patients aged 15-60 years with a history of drug abuse. The participants were categorized into three age groups. The comparative analysis involved 113 reference subjects of the same age groups. The sample preparation employed microwave-assisted acid digestion, and the toxic elements were quantified using atomic absorption spectrophotometry. Accuracy was ensured using certified reference materials for hair, whole blood, and serum samples. Drug-addicted subjects had significantly higher concentrations of toxic elements (arsenic, cadmium, mercury, and nickel) in biological samples than referent subjects (p > 0.001). Elevated levels of these toxic elements may increase susceptibility to infections, possibly due to malnutrition, drug-related effects, and additional contaminants. These findings necessitate further studies to explore the long-term health outcomes, potential treatment options, and broader socioeconomic impacts of substance abuse. This study serves as a baseline for future research in this critical public health field.
摘要：
吸毒成瘾与重大健康风险有关，包括心血管并发症,癌症,和精神障碍。非法药物,如大麻素和阿片类药物，包括处方药,被广泛消费并对健康产生深远的影响。了解这些物质中有毒元素的健康影响对于预防过量和有效的恢复策略至关重要。本研究旨在确定有毒元素，包括砷（As），镉(Cd),汞(Hg),和镍（Ni），在大麻素和阿片类药物以及生物样品(全血，头皮毛发,和血清）来自311名15-60岁有药物滥用史的男性药物滥用患者。参与者被分为三个年龄组。比较分析涉及相同年龄段的113名参考受试者。样品制备采用微波辅助酸消解，用原子吸收分光光度法对有毒元素进行定量。使用经认证的头发参考材料确保准确性，全血,和血清样本.吸毒成瘾的受试者的毒性元素浓度明显较高（砷，镉,水银,和镍）在生物样品中比参考对象（p>0.001）。这些有毒元素的水平升高可能会增加感染的易感性，可能是因为营养不良,药物相关的影响，和额外的污染物。这些发现需要进一步的研究来探索长期的健康结果，潜在的治疗选择，以及药物滥用的更广泛的社会经济影响。这项研究是未来在这一关键公共卫生领域研究的基线。
