Abstract：
Low-level light therapy (LLLT), also known as photo biomodulation (PBM), is a type of optical therapy that uses red or near-infrared lasers or light-emitting diodes (LEDs) for medical treatment. The laser wavelengths involved in PBM typically range between 600-700 nm and 780-1100 nm, with power densities ranging between 5 mW/cm2 and 5 W/cm2. PBM is a series of biochemical cascades exhibited by biological tissues after absorbing a certain amount of energy from light. PBM has been widely used in clinical practice in the past 20 years, and numerous clinical trials have demonstrated its biological efficacy. However, the underlying mechanisms have not yet been fully explored. In this paper, we have summarized the research into PBM over the past two decades, to identify the important mechanisms of the biological effects of PBM from the perspective of molecular mechanisms, cellular levels, and tissue changes. We hope our study provide a theoretical basis for future investigations into the underlying mechanisms.
摘要：
低水平光疗（LLLT），也称为光生物调制(PBM)，是一种使用红色或近红外激光器或发光二极管（LED）进行医疗的光学疗法。PBM中涉及的激光波长通常在600-700nm和780-1100nm之间，功率密度范围在5mW/cm2和5W/cm2之间。PBM是生物组织在吸收一定量的光能后表现出的一系列生化级联反应。PBM在过去的20年中在临床实践中得到了广泛的应用，许多临床试验证明了它的生物学功效。然而,基本机制尚未得到充分探索。在本文中,我们总结了过去二十年来对PBM的研究，从分子机制的角度确定PBM生物学效应的重要机制，细胞水平，和组织变化。我们希望我们的研究为未来对潜在机制的研究提供理论基础。
