Abstract：
The physicochemical characteristics of fatty acid (FA) vesicles and their ion sensitivity as drug delivery vehicles in an ion-competitive environment have received much attention. Here, we show that in a Na+/K+ competitive ionic environment, FA vesicles undergo a cascade of periodic expansion and selective ion retention in response to osmotic attack. When the Na+/K+ ratio is altered, the expansion and volume of vesicles are affected and the ions in vesicles mix with the hyperosmotic fluid to produce a stable transmembrane potential, consistent with the Donnan effect and iontophoresis theory. Furthermore, osmotic swelling experiments suggest that FA vesicles are more easily maintained in a single Na+ or K+ solution than in a multicomponent ion competition system. As a theoretical basis for the utilization of FA vesicles in multicomponent ionic environments, we developed a core theoretical model to characterize the basic features of the volume fluctuations of FA vesicles in ion-competing environments.
摘要：
脂肪酸（FA）囊泡的理化特性及其在离子竞争环境中作为药物递送载体的离子敏感性备受关注。这里,我们表明，在Na+/K+竞争的离子环境中，FA囊泡响应于渗透攻击而经历周期性膨胀和选择性离子保留的级联。当Na+/K+比值改变时，囊泡的膨胀和体积受到影响，囊泡中的离子与高渗液混合产生稳定的跨膜电位，与Donnan效应和离子电渗疗法理论一致。此外，渗透溶胀实验表明，FA囊泡在单一Na或K溶液中比在多组分离子竞争系统中更容易维持。作为在多组分离子环境中利用FA囊泡的理论基础，我们开发了一个核心理论模型来表征离子竞争环境中FA囊泡体积波动的基本特征。
