Abstract：
The purpose of this review is to identify key classes of medications that are used for the treatment of older adults with neurocognitive disorders.
Clinical factors play a critical role in the prescribing of these medication classes for the treatment of dementia. The variation in prescribing trends is determined by the presence of medical and psychiatric comorbidities commonly occurring in older adults and is based on the consideration of potential interactions between pharmacotherapies for the comorbidities and for the dementia. Six medication classes currently exist to address the neurocognitive aspect of dementia, with varying pharmacokinetic and pharmacodynamic profiles. We review these six classes in this report and provide a provision of clinical insights regarding the use of these agents. While literature exists on the safety and efficacy of individual medication options for the treatment of dementia in the older adult population, further research is needed to provide clearer guidance regarding the specific use of these agents in clinical practice.
Clinical factors play a critical role in the prescribing of these medication classes for the treatment of dementia. The variation in prescribing trends is determined by the presence of medical and psychiatric comorbidities commonly occurring in older adults and is based on the consideration of potential interactions between pharmacotherapies for the comorbidities and for the dementia. Six medication classes currently exist to address the neurocognitive aspect of dementia, with varying pharmacokinetic and pharmacodynamic profiles. We review these six classes in this report and provide a provision of clinical insights regarding the use of these agents. While literature exists on the safety and efficacy of individual medication options for the treatment of dementia in the older adult population, further research is needed to provide clearer guidance regarding the specific use of these agents in clinical practice.
摘要：
目的：本综述的目的是确定用于治疗患有神经认知障碍的老年人的关键药物类别。
结果：临床因素在这些治疗痴呆症的药物种类的处方中起着至关重要的作用。处方趋势的变化取决于老年人中常见的医学和精神病学合并症的存在，并且基于对合并症和痴呆症药物治疗之间潜在相互作用的考虑。目前存在六种药物类别来解决痴呆症的神经认知方面，具有不同的药代动力学和药效学特征。我们在本报告中回顾了这六个类别，并提供了有关这些药物使用的临床见解。虽然有文献研究老年人群痴呆的个别药物治疗方案的安全性和有效性，对于这些药物在临床实践中的具体使用,需要进一步的研究提供更明确的指导.
结果：临床因素在这些治疗痴呆症的药物种类的处方中起着至关重要的作用。处方趋势的变化取决于老年人中常见的医学和精神病学合并症的存在，并且基于对合并症和痴呆症药物治疗之间潜在相互作用的考虑。目前存在六种药物类别来解决痴呆症的神经认知方面，具有不同的药代动力学和药效学特征。我们在本报告中回顾了这六个类别，并提供了有关这些药物使用的临床见解。虽然有文献研究老年人群痴呆的个别药物治疗方案的安全性和有效性，对于这些药物在临床实践中的具体使用,需要进一步的研究提供更明确的指导.
