PDF(Pubmed)
Abstract：
Parkinson\'s disease (PD) is a common, prevalent neurodegenerative disease. It is mainly characterized by motor symptoms such as rigidity, tremors, and bradykinesia, but it can also manifest with non-motor symptoms, of which depression is the most frequent. The latter can impair the quality of life, yet it gets overlooked and goes untreated because of the significant overlap in their clinical features, hence making the diagnosis difficult. Furthermore, there is limited data on the availability of appropriate criteria for making the diagnosis of depression in PD patients, as it can occur with varying expressions throughout the course of PD or it can also precede it. This review article has included a brief discussion on the diagnosis of depression in PD patients and their overlapped clinical manifestations. Understanding the mechanisms underlying the disease processes of PD and depression and the pathways interconnecting them gives better knowledge on devising treatment options for the patients. Only studies from Pubmed were included and all other databases were excluded. Studies from the last 50 years were included. Suitable references included in these studies were also extracted. Thus, depression in PD and PD in depression, along with their pharmacological and non-pharmacological treatment options, have been discussed.
摘要：
帕金森病(PD)是一种常见的疾病,普遍的神经退行性疾病。它的主要特征是运动症状，如僵硬，震颤,和运动迟缓，但它也可以表现为非运动症状，其中抑郁症是最常见的。后者会损害生活质量，然而，由于其临床特征的显著重叠，它被忽略并未经治疗，使诊断变得困难。此外，关于PD患者抑郁症诊断的适当标准的数据有限，因为它可以在整个PD过程中以不同的表达式发生，也可以先于它。本文对PD患者抑郁症的诊断及其重叠临床表现进行了简要讨论。了解PD和抑郁症疾病过程的潜在机制以及将它们相互连接的途径，可以更好地了解为患者设计治疗方案。仅纳入Pubmed的研究，排除所有其他数据库。包括过去50年的研究。还提取了这些研究中包括的合适的参考文献。因此，PD中的抑郁症和PD中的抑郁症，连同他们的药理学和非药理学治疗选择，已经讨论过了。
