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Abstract：
Oral squamous cell carcinoma (OSCC) affects a large number of individuals worldwide. Despite advancements in surgery, radiation, and chemotherapy, satisfactory outcomes have not been achieved. In recent years, the success of drugs targeting programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) has led to breakthroughs in cancer treatment, but systematic summaries on their effectiveness against OSCC are lacking. This article reviews the latest research on the PD-1/PD-L1 pathway and the potential of combination therapy based on this pathway in OSCC. Further, it explores the mechanisms involved in the interaction of this pathway with exosomes and protein-protein interactions, and concludes with potential future OSCC therapeutic strategies.
摘要：
口腔鳞状细胞癌(OSCC)影响全世界的大量个体。尽管手术取得了进步，辐射,和化疗，尚未取得令人满意的结果。近年来,靶向程序性细胞死亡1（PD-1）和程序性细胞死亡配体1（PD-L1）的药物的成功导致了癌症治疗的突破，但缺乏对其对抗OSCC有效性的系统总结。本文综述了PD-1/PD-L1通路的最新研究以及基于该通路的联合治疗OSCC的潜力。Further,它探讨了该途径与外泌体相互作用和蛋白质-蛋白质相互作用的机制，最后提出了未来潜在的OSCC治疗策略。
