PDF(Pubmed)
Abstract：
UNASSIGNED: Subclinical hypothyroidism (SH) is particularly frequent in individuals with Down syndrome (DS). Despite the amount of evidence suggesting SH is associated with psychopathological symptoms and sleep problems in general population, poor is known about the emotional and behavioral features associated with SH in children with DS.
UNASSIGNED: The first aim of the current study was to investigate differences in emotional and behavioral profiles between a group of children with DS exhibiting co-occurring SH and a group of age and BMI-matched children with DS without co-occurring SH. The second aim of the present study was to investigate differences in sleep disturbances between these groups.
UNASSIGNED: We included in this retrospective study 98 participants with DS aged 3-18 years with the aim to explore differences in emotional/behavioral problems as well as in sleep difficulties between children with DS with or without co-occurring SH.
UNASSIGNED: Participants with co-occurring SH exhibited significantly higher scores at several scales of the Conners\' Parent Rating Scales Long Version - Revised. However, they did not exhibit more sleep problems than control group.
UNASSIGNED: These results provide specific indications for psychological and neuropsychiatric evaluation of children with DS with suspected or diagnosed SH, highlighting the importance of a multidisciplinary approach in clinical care for children and adolescents with DS.
UNASSIGNED: The first aim of the current study was to investigate differences in emotional and behavioral profiles between a group of children with DS exhibiting co-occurring SH and a group of age and BMI-matched children with DS without co-occurring SH. The second aim of the present study was to investigate differences in sleep disturbances between these groups.
UNASSIGNED: We included in this retrospective study 98 participants with DS aged 3-18 years with the aim to explore differences in emotional/behavioral problems as well as in sleep difficulties between children with DS with or without co-occurring SH.
UNASSIGNED: Participants with co-occurring SH exhibited significantly higher scores at several scales of the Conners\' Parent Rating Scales Long Version - Revised. However, they did not exhibit more sleep problems than control group.
UNASSIGNED: These results provide specific indications for psychological and neuropsychiatric evaluation of children with DS with suspected or diagnosed SH, highlighting the importance of a multidisciplinary approach in clinical care for children and adolescents with DS.
摘要：
■亚临床甲状腺功能减退症（SH）在唐氏综合征（DS）患者中尤其常见。尽管大量证据表明SH与一般人群的精神病理学症状和睡眠问题有关，在DS儿童中，与SH相关的情绪和行为特征较差。
■本研究的第一个目的是调查一组表现出共同发生的SH的DS儿童与一组年龄和BMI匹配的DS儿童之间的情绪和行为特征差异。没有共同发生的SH。本研究的第二个目的是调查这些群体之间睡眠障碍的差异。
■我们在这项回顾性研究中纳入了98名年龄在3-18岁的DS参与者，目的是探索有或没有合并SH的DS儿童在情绪/行为问题以及睡眠困难方面的差异。
■同时出现SH的参与者在Conners父母评定量表长版本的几个量表上表现出明显更高的分数-修订版。然而,他们没有表现出更多的睡眠问题比对照组。
■这些结果为怀疑或诊断为SH的DS患儿的心理和神经精神评估提供了具体的指征，强调多学科方法在DS儿童和青少年临床护理中的重要性。
■本研究的第一个目的是调查一组表现出共同发生的SH的DS儿童与一组年龄和BMI匹配的DS儿童之间的情绪和行为特征差异。没有共同发生的SH。本研究的第二个目的是调查这些群体之间睡眠障碍的差异。
■我们在这项回顾性研究中纳入了98名年龄在3-18岁的DS参与者，目的是探索有或没有合并SH的DS儿童在情绪/行为问题以及睡眠困难方面的差异。
■同时出现SH的参与者在Conners父母评定量表长版本的几个量表上表现出明显更高的分数-修订版。然而,他们没有表现出更多的睡眠问题比对照组。
■这些结果为怀疑或诊断为SH的DS患儿的心理和神经精神评估提供了具体的指征，强调多学科方法在DS儿童和青少年临床护理中的重要性。
