PDF(Pubmed)
Abstract：
Bisphenol A (BPA) is an oil-derived, large-market volume chemical with endocrine disrupting properties and reproductive toxicity. Moreover, BPA is frequently used in food contact materials, has been extensively researched recently, and widespread exposure in the general population has been reported worldwide. However, national information on BPA levels in general Chinese people is lacking.
This study collected and analyzed 145 (104 in urine and 41 in serum) research articles published between 2004 and 2021 to reflect the BPA internal exposure levels in Chinese populations. The Monte Carlo simulation method is employed to analyze and estimate the data in order to rectify the deviation caused by a skewed distribution.
Data on BPA concentrations in urine and serum were collected from 2006 to 2019 and 2004 to 2019, respectively. Urinary BPA concentrations did not vary significantly until 2017, with the highest concentration occurring from 2018 to 2019 (2.90 ng/mL). The serum BPA concentration decreased to the nadir of 1.07 ng/mL in 2011 and gradually increased to 2.54 ng/mL. Nationally, 18 provinces were studied, with Guangdong (3.50 ng/mL), Zhejiang (2.57 ng/mL), and Fujian (2.15 ng/mL) having the highest urine BPA levels. Serum BPA was investigated in 15 provinces; Jiangsu (9.14 ng/mL) and Shandong (5.80 ng/mL) were relatively high. The results also indicated that males\' urine and serum BPA levels were higher than females, while the BPA levels in children were also higher than in adults (p < 0.001). Furthermore, the volume of garbage disposal (r = 0.39, p < 0.05), household sewage (r = 0.34, p < 0.05), and waste incineration content (r = 0.35, p < 0.05) exhibited a strong positive connection with urine BPA levels in Chinese individuals.
Despite using a data consolidation approach, our study found that the Chinese population was exposed to significant amounts of BPA, and males having a higher level than females. Besides, the levels of BPA exposure are influenced by the volume of garbage disposal, household sewage, and waste incineration content.
This study collected and analyzed 145 (104 in urine and 41 in serum) research articles published between 2004 and 2021 to reflect the BPA internal exposure levels in Chinese populations. The Monte Carlo simulation method is employed to analyze and estimate the data in order to rectify the deviation caused by a skewed distribution.
Data on BPA concentrations in urine and serum were collected from 2006 to 2019 and 2004 to 2019, respectively. Urinary BPA concentrations did not vary significantly until 2017, with the highest concentration occurring from 2018 to 2019 (2.90 ng/mL). The serum BPA concentration decreased to the nadir of 1.07 ng/mL in 2011 and gradually increased to 2.54 ng/mL. Nationally, 18 provinces were studied, with Guangdong (3.50 ng/mL), Zhejiang (2.57 ng/mL), and Fujian (2.15 ng/mL) having the highest urine BPA levels. Serum BPA was investigated in 15 provinces; Jiangsu (9.14 ng/mL) and Shandong (5.80 ng/mL) were relatively high. The results also indicated that males\' urine and serum BPA levels were higher than females, while the BPA levels in children were also higher than in adults (p < 0.001). Furthermore, the volume of garbage disposal (r = 0.39, p < 0.05), household sewage (r = 0.34, p < 0.05), and waste incineration content (r = 0.35, p < 0.05) exhibited a strong positive connection with urine BPA levels in Chinese individuals.
Despite using a data consolidation approach, our study found that the Chinese population was exposed to significant amounts of BPA, and males having a higher level than females. Besides, the levels of BPA exposure are influenced by the volume of garbage disposal, household sewage, and waste incineration content.
摘要：
■双酚A（BPA）是一种油衍生的，具有内分泌干扰特性和生殖毒性的大市场容量化学品。此外，BPA经常用于食品接触材料中，最近进行了广泛的研究，并且在世界范围内广泛暴露于普通人群中。然而,缺乏关于一般中国人BPA水平的国家信息。
■这项研究收集并分析了2004年至2021年之间发表的145篇（尿液中104篇，血清中41篇）研究文章，以反映中国人群中BPA的内部暴露水平。为了纠正由偏斜分布引起的偏差，采用蒙特卡罗模拟方法对数据进行分析和估计。
■分别从2006年至2019年和2004年至2019年收集了尿液和血清中BPA浓度的数据。直到2017年，尿BPA浓度没有显着变化，最高浓度发生在2018年至2019年（2.90ng/mL）。血清BPA浓度在2011年下降至最低点1.07ng/mL,逐渐上升至2.54ng/mL。在全国范围内,研究了18个省，广东（3.50纳克/毫升），浙江（2.57ng/mL），和福建（2.15ng/mL）具有最高的尿BPA水平。在15个省份进行了血清BPA调查；江苏（9.14ng/mL）和山东（5.80ng/mL）相对较高。结果还表明，男性尿液和血清BPA水平高于女性，而儿童的BPA水平也高于成人（p<0.001）。此外，垃圾处理量(r=0.39，p<0.05)，生活污水(r=0.34，p<0.05)，垃圾焚烧含量（r=0.35，p<0.05）与中国人尿液中BPA水平呈正相关。
■尽管使用了数据整合方法，我们的研究发现，中国人暴露于大量的双酚A，男性的水平高于女性。此外,BPA暴露水平受垃圾处理量的影响，生活污水,和垃圾焚烧的内容。
■这项研究收集并分析了2004年至2021年之间发表的145篇（尿液中104篇，血清中41篇）研究文章，以反映中国人群中BPA的内部暴露水平。为了纠正由偏斜分布引起的偏差，采用蒙特卡罗模拟方法对数据进行分析和估计。
■分别从2006年至2019年和2004年至2019年收集了尿液和血清中BPA浓度的数据。直到2017年，尿BPA浓度没有显着变化，最高浓度发生在2018年至2019年（2.90ng/mL）。血清BPA浓度在2011年下降至最低点1.07ng/mL,逐渐上升至2.54ng/mL。在全国范围内,研究了18个省，广东（3.50纳克/毫升），浙江（2.57ng/mL），和福建（2.15ng/mL）具有最高的尿BPA水平。在15个省份进行了血清BPA调查；江苏（9.14ng/mL）和山东（5.80ng/mL）相对较高。结果还表明，男性尿液和血清BPA水平高于女性，而儿童的BPA水平也高于成人（p<0.001）。此外，垃圾处理量(r=0.39，p<0.05)，生活污水(r=0.34，p<0.05)，垃圾焚烧含量（r=0.35，p<0.05）与中国人尿液中BPA水平呈正相关。
■尽管使用了数据整合方法，我们的研究发现，中国人暴露于大量的双酚A，男性的水平高于女性。此外,BPA暴露水平受垃圾处理量的影响，生活污水,和垃圾焚烧的内容。
