PDF(Pubmed)
Abstract：
The current study aims to assess the prevalence of different genera of Rickettsiales, intracellular bacteria, in dogs across various regions of Iran. Rickettsiales, as zoonotic pathogens, can have various manifestations in different species, including immunosuppression, anaemia and neuropathy. Due to their close interactions with people and livestock, dogs can serve as reservoirs and transmit these pathogens to humans and other animals. The data from this research can be valuable for managing and controlling related diseases and complications in Iran and possibly neighbouring countries. Pertinent data for this study was gathered without time limitations until 1 March 2022, from different databases. Of all the inspected studies, 26 were eligible based on the inclusion criteria. The Egger test result and asymmetry in the funnel plot revealed significant publication bias; therefore, the meta-analysis model was corrected with the trim-and-fill method. After correction, the prevalence of rickettsial infections among dogs varies by genus - 20.1% for Anaplasma spp. and 10% for Ehrlichia spp. - with an overall prevalence estimated at 18.3% by random-effects analysis. The highest and lowest estimated pooled prevalences were associated with the southwestern (38.5%) and southern (0.3%) provinces of Iran, respectively. The pooled prevalence of rickettsial infection was higher in female dogs (OR = 1.198; p < 0.978; 95% CI, 0.842-1.705) and in dogs ≤2 years (OR = 1.014; p < 0.312; 95% CI, 0.598-1.72), but the difference was not statistically significant. Ultimately, the pooled prevalence of rickettsial infections among dogs is relatively low compared to other countries like Qatar, Iraq, Saudi Arabia and Turkey, which are nearby Iran. Given the significant clinical outcomes of this disease, necessary measures for prevention should be taken.
摘要：
本研究旨在评估立克次体不同属的患病率，胞内细菌，在伊朗不同地区的狗中。Rickettsiales,作为人畜共患病原体，可以在不同的物种中有各种表现，包括免疫抑制,贫血和神经病。由于它们与人和牲畜的密切互动，狗可以作为水库，并将这些病原体传播给人类和其他动物。这项研究的数据对于管理和控制伊朗及其邻国的相关疾病和并发症可能是有价值的。这项研究的相关数据是在2022年3月1日之前从不同的数据库收集的，没有时间限制。在所有被检查的研究中，根据纳入标准，有26人符合资格。Egger测试结果和漏斗图中的不对称性揭示了显著的发表偏倚；因此，荟萃分析模型采用修剪填充法进行校正.校正后,犬类立克次体感染的患病率因属而异-无性体属为20.1%。埃里希菌属10%。-根据随机效应分析，总体患病率估计为18.3%。估计合并患病率最高和最低的省份与伊朗的西南部（38.5％）和南部（0.3％）省份有关，分别。雌犬的立克次体感染的合并患病率较高（OR=1.198；p<0.978；95％CI，0.842-1.705）和≤2岁的犬（OR=1.014；p<0.312；95％CI，0.598-1.72），但差异无统计学意义。最终,与卡塔尔等其他国家相比，狗的立克次体感染的合并患病率相对较低，伊拉克,沙特阿拉伯和土耳其,就在伊朗附近。鉴于这种疾病的显著临床结果，应采取必要的预防措施。
